@ARTICLE{Wang_Y.B._Perspectives_2018,
 author={Wang, Y.B. and Wang, L.P. and Li, P.},
 volume={vol. 21},
 number={No 3},
 journal={Polish Journal of Veterinary Sciences},
 pages={643–649},
 howpublished={online},
 year={2018},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a patho- gen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have expe- rienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced im- munity ineffective. In addition, vaccine development has been hampered due to problems includ- ing difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neu- tralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we re- view the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vac- cines.},
 type={Review / Artykuł przeglądowy},
 title={Perspectives on novel vaccine development},
 URL={http://journals.pan.pl/Content/108456/PDF/30.pdf},
 doi={10.24425/124302},
 keywords={vaccination, vaccinology, novel vaccine development, perspectives},
}