@ARTICLE{Zhang_Y._Caspase-1_2020,
 author={Zhang, Y. and Yang, T. and Huang, F.},
 volume={vol. 23},
 number={No 4},
 journal={Polish Journal of Veterinary Sciences},
 pages={605-610},
 howpublished={online},
 year={2020},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={The pathogenesis of porcine contagious pleuropneumonia is poorly understood. In the present study, a mouse model of intranasal infection by Actinobacillus pleuropneumoniae (App) was used to examine lung inflammation. The pathogical results of lung tissues showed that App-infected mice showed dyspnea and anorexia, with severe damage by acute hemorrhage, and infiltration of eosinophils and lymphocytes, as well as increased expression of caspase-1 p20, interleukin (IL)-1β, IL-6, IL-8, IL-18 and tumor necrosis factor (TNF)-α. Caspase-1 inhibitors reduced both lung tissue damage and the expression of caspase-1 p20, IL-1β, IL-6, IL-8, TNF-α and IL-18 in infected mice. These findings suggest that the caspase-1 dependent pyroptosis involved in the pathogenesis of the mouse pleuropneumonia caused by App and the inhibition of caspase-1 reduced the lung injury of this pleuropneumonia},
 type={Article},
 title={Caspase-1 inhibitor reduced the lung injury in a mouse model of pleuropneumonia caused by Actinobacillus pleuropneumoniae},
 URL={http://journals.pan.pl/Content/118733/PDF/16.pdf},
 doi={10.24425/pjvs.2020.135807},
 keywords={porcine contagious pleuropneumonia, mice, caspase-1 inhibitors, caspase-1dependent pyroptosis},
}