TY - JOUR N2 - Pancreatic ductal adenocarcinoma (PDAC) is characterized by very poor prognosis. It is caused by asymptomatic course of the disease at early stage. Symptomatic PDAC means usually advanced stage of the disease, making radical treatment impossible. Finding of biological PDAC marker could improve PDAC treatment through early diagnosis. In our study, we investigated two adipokines: omentin and chemerin concentration in PDAC, chronic pancreatitis (CP) and healthy individuals. We examined 27 PDAC patients, 10 CP patients and 36 controls. To determine concentration of adipokines we used ELISA immunoenzymatic assay. Level of both adipokines was increased when comparing control group to PDAC patients. Additionally, chemerin concentration in CP group was elevated comparing to control. To evaluate both adipokines as potential PDAC biomarkers we performed ROC analysis. Chemerin (AUC = 0.913) displayed better discriminant ability than omentin-1 (AUC = 0.73). Some authors believe that chemerin may promote tumour growth by stimulating angiogenesis and is supposed to be a factor recruiting mesenchymal stroma cells (MSC) in tumour regions. Omentin-1 can inhibit tumourigenesis by TP53 stimulation. On the other hand, according to some studies, omentin-1 may promote cancer proliferation via Akt signalling pathway. Results from our study showed signifi cantly elevated level of chemerin and omentin-1 in PDAC patients. Th erefore, w e believe that both investigated adipokines may provide promising and novel pharmacological insights for oncological diagnosis in the near future. L1 - http://journals.pan.pl/Content/108795/PDF/FMC%202-18%207-Kiczmer.pdf L2 - http://journals.pan.pl/Content/108795 PY - 2018 IS - No 2 EP - 87 DO - 10.24425/fmc.2018.124660 KW - omentin-1 KW - chemerin KW - pancreatic cancer KW - adipose tissue KW - adipokine KW - pancreatitis A1 - Kiczmer, Paweł A1 - Szydło, Błażej A1 - Prawdzic Seńkowska, Alicja A1 - Jopek, Janusz A1 - Wiewióra, Maciej A1 - Piecuch, Jerzy A1 - Ostrowska, Zofia A1 - Świętochowska, Elżbieta PB - Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum VL - vol. 58 DA - 2018.06.30 T1 - Serum omentin-1 and chemerin concentrations in pancreatic cancer and chronic pancreatitis SP - 77 UR - http://journals.pan.pl/dlibra/publication/edition/108795 T2 - Folia Medica Cracoviensia ER -