TY - JOUR N2 - Background: Anorexia nervosa is a widely prevalent eating disorder that often leads to life-threatening complications. Since it mostly concerns females, many authors have focused on studying the reproductive system in anorexic women. Recently discovered telocytes may give a new insight into the pathophysiology of gynecological complications in these patients. Material and Methods: We adopted an animal model of anorexia nervosa induced by voluntary physical activity. Sixteen female Wistar rats were divided into two groups: control and activity-based anorexia. When the weight loss of activity-based anorexia (ABA) rats reached 25% animals were euthanized. Size and weight measurements as well as histopathological analysis of the reproductive organs were performed. Additionally, we used immunohistochemical staining for detection of telocytes. Results: Telocytes were identified in uteri of anorectic rats but no diff erences were observed when compared to the control group. Nevertheless, in the ABA group the weight of the uteri and the number of follicles in the ovaries decreased significantly. Conclusions: Our rat model of anorexia nervosa mimics the effects of this eating disorder that occur in the female reproductive system since we reported ovarian dysfunction and uterine involution in the experimental animals. It supports its potential role in the further studies of anorexia pathophysiology and treatment possibilities. L1 - http://journals.pan.pl/Content/109119/PDF-MASTER/pan_doi_blank.pdf L2 - http://journals.pan.pl/Content/109119 PY - 2018 IS - No 3 EP - 125 DO - 10.24425/fmc.2018.125077 KW - anorexia nervosa KW - rat KW - uterus KW - ovaries KW - telocytes A1 - Skowron, Kamil A1 - Aleksandrovych, Veronika A1 - Kurnik-Łucka, Magdalena A1 - Stach, Paulina A1 - Baranowska, Agnieszka A1 - Skowron, Beata A1 - Gil, Krzysztof PB - Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum VL - vol. 58 DA - 2018.09.30 T1 - Aberrations in the female reproductive organs and a role of telocytes in a rat model of anorexia nervosa SP - 115 UR - http://journals.pan.pl/dlibra/publication/edition/109119 T2 - Folia Medica Cracoviensia ER -