TY - JOUR N2 - The pharmacokinetics of a diclofenac sodium was investigated in swine. A single intravenous (i.v.) or intramuscular (i.m.) injection of 5% diclofenac sodium (concentration = 2.5 mg · kg-1) was administered to 8 healthy pigs according to a two-period crossover design. The pharmacokinetic parameters were calculated by non-compartmental analysis with DAS2.1.1 software. After a single i.v. administration, the main pharmacokinetic parameters of diclofenac sodium injection in swine were as follows: the elimination half-time (T1/2β) was 1.32±0.34 h; the area under the curve (AUC) was (55.50±5.50 μg · mL-1 h; the mean residence time (MRT) was 1.60±0.28 h; the apparent volume of distribution (Vd) was 0.50±0.05 L · kg-1; and the body clearance (CLB) was 0.26±0.04 L · (h · kg)-1. After the single i.m. administration, the pharmacokinetic parameters were as follows: peak time (Tmax) was 1.19±0.26 h; and peak concentration (Cmax) was 11.61±5.99 μg mL-1. The diclofenac sodium has the following pharmacokinetic characteristics in swine: rapid absorption and elimination; high peak concentration; and bioavailability. L1 - http://journals.pan.pl/Content/112764/PDF/29.pdf L2 - http://journals.pan.pl/Content/112764 PY - 2019 IS - No 2 EP - 426 DO - 10.24425/pjvs.2019.129217 KW - diclofenac sodium injection KW - pharmacokinetics KW - bioavailability KW - swine KW - HPLC A1 - Yang, H.F. A1 - Li, Y.J. A1 - Li, Y.Y. A1 - Huang, C. A1 - Huang, L.X. A1 - Bu, S.J. PB - Polish Academy of Sciences Committee of Veterinary Sciences PB - University of Warmia and Mazury in Olsztyn VL - vol.22 DA - 2019.07.01 T1 - Pharmacokinetics of diclofenac sodium injection in swine SP - 423 UR - http://journals.pan.pl/dlibra/publication/edition/112764 T2 - Polish Journal of Veterinary Sciences ER -