TY - JOUR N2 - Steroidal saponins isolated from many plant species belonging to Monocotyledones display potent cytotoxic activity towards many human tumor cells. We examined the cytotoxic effects of crude Paris quadrifolia extract for the first time, testing isolated saponin-rich fractions against four different human cell lines using the [(3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was tested against human promyelocytic leukemia (HL-60) cells, human cervical adenocarcinoma (HeLa) cells and human breast cancer (MDA-MB-468) cells. Human skin fibroblasts were used as non-neoplastic control cells. Our results show significant activity of the weakly water-soluble solid residue and butanolic fraction against HL-60 and HeLa cells. The solid residue exerted cytotoxicity against all tested cell lines. L1 - http://journals.pan.pl/Content/81747/PDF/abc_53_2_16.pdf L2 - http://journals.pan.pl/Content/81747 PY - 2011 IS - No 2 DO - 10.2478/v10182-011-0024-1 KW - In vitro cytotoxicity KW - MTT assay KW - Paris quadrifolia extract KW - steroidal saponins KW - human tumor cell lines A1 - Stefanowicz-Hajduk, Justyna A1 - Kawiak, Anna A1 - Gajdus, Jerzy A1 - Ochocka, J. A1 - Paszkiewicz, Monika A1 - Stepnowski, Piotr A1 - Łojkowska, Ewa PB - Biological Commission of the Polish Academy of Sciences – Cracow Branch VL - vol. 53 DA - 2011 T1 - Cytotoxic Activity of Paris quadrifolia Extract and Isolated Saponin Fractions Against Human Tumor Cell Lines UR - http://journals.pan.pl/dlibra/publication/edition/81747 T2 - Acta Biologica Cracoviensia s. Botanica ER -