Tytuł artykułu

A role of ghrelin in cancerogenesis

Tytuł czasopisma

Polish Journal of Veterinary Sciences




No 1

Autorzy publikacji

Wydział PAN

Nauki Biologiczne i Rolnicze


University of Warmia and Mazury in Olsztyn ; Polish Academy of Sciences Committee of Veterinary Sciences




ISSN 1505-1773


Alnema M. (2010), Ghrelin and obestatin expression in oral squamous cell carcinoma: an immunohistochemical and biochemical study, Mol Cell Biochem, 339, 173, ; Arnaldi G. (2003), Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors, J Clin Endocrinol Metab, 88, 5834, ; Barzon L. (2005), Loss of growth hormone secretagogue receptor 1a and overexpression of type 1b receptor transcripts in human adrenocortical tumors, Oncology, 68, 414, ; Bednarek M. (2000), Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a, J Med Chem, 43, 4370, ; Bhatti S. (2006), Effects of food intake and food withholding on plasma ghrelin concentrations in healthy dogs, Am J Vet Res, 67, 1557, ; Broglio F. (2004), Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans, J Clin Endocrinol Metab, 89, 3062, ; Cassoni P. (2000), Specific binding sites for synthetic growth hormone secretagogues in non-tumoral and neoplastic human thyroid tissue, J Endocrinol, 165, 139, ; Cassoni P. (2001), Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinoma and cell lines, J Clin Endocrinol Metab, 86, 1738, ; Cassoni P. (2004), Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines, Eur J Endocrinol, 150, 173, ; Cowley M. (2003), The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis, Neuron, 37, 649, ; Dagli A. (2009), Ghrelin expression in normal kidney tissue and renal carcinomas, Pathol Res Pract, 205, 165, ; Date Y. (2000), Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans, Endocrinology, 141, 4255, ; C. De Vriese (2004), Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sites, Endocrinology, 145, 4997, ; C. De Vriese (2007), Ghrelin: A new peptide regulating growth hormone release and food intake, Int J Biochem Cell Biol, 40, 1420, ; Delhanty P. (2006), Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a, J Endocrinol, 188, 37, ; Delhanty P. (2007), Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway, Am J Physiol Endocrinol Metab, 293. ; Dixit V. (2006), Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility, J Biol Chem, 281, 16681, ; Duxbury M. (2003), Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness, Biochem Biophys Res Commun, 309, 464, ; Ekeblad S. (2007), Co-expression of ghrelin and its receptor in pancreatic endocrine tumours, Clin Endocrinol (Oxf), 66, 115. ; Fukushima N. (2005), Ghrelin directly regulates bone formation, J Bone Miner Res, 20, 790, ; Gauna C. (2005), Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes, J Clin Endocrinol Metab, 90, 1055, ; Gauna C. (2007), Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R), Mol Cell Endocrinol, 274, 30, ; Gaytan F. (2004), Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors, J Clin Endocrinol Metab, 89, 400, ; Gaytan F. (2005), Expression of growth hormone secretagogue receptor type 1a, the functional ghrelin receptor, in human ovarian surface epithelium, mullerian duct derivatives, and ovarian tumors, J Clin Endocrinol Metab, 90, 1798, ; Ghe C. (2002), The anti-proliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells, Endocrinology, 143, 484, ; Gnanapavan S. (2002), The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans, J Clin Endocrinol Metab, 87, 2988, ; Hattori N. (2001), GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils, J Clin Endocrinol Metab, 86, 4284, ; Hayashida T. (2001), Ghrelin in domestic animals: distribution in stomach and its possible role, Domest Anim Endocrinol, 21, 17, ; Hashizume T. (2003), Effects of Ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs, Domest Anim Endocrinol, 24, 209, ; Hashizume T. (2003), Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle, Endocr J, 50, 289, ; He X. (2011), Ghrelin inhibites 5-fluorouracil-induced apoptosis in colonic cancer cells, J Gastroenterol Hepatol, 26, 1169, ; Hosoda H. (2000), Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor, J Biol Chem, 275, 21995, ; Hosoda H. (2006), Biological, physiological and pharmacological aspects of ghrelin, J Pharmacol Sci, 100, 398, ; Howard A. (1996), A receptor in pituitary and hypothalamus that functions in growth hormone release, Science, 273, 974, ; Ida T. (2007), Purification and characterization of feline ghrelin and its possible role, Domest Anim Endocrinol, 32, 93, ; Isgaard J. (2005), Ghrelin and GHS on cardiovascular applications/functions, J Endocrinol Invest, 28, 838. ; Jeffery P. (2002), Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines, J Endocrinol, 172. ; Jeffery P. (2003), The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer, Cytokine Growth Factor Rev, 14, 113, ; Jeffery P. (2005), Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell lines, Endocr Relat Cancer, 12, 839, ; Jeusette I. (2005), Influence of obesity on plasma lipid and lipoprotein concentrations in dogs, Am J Vet Res, 66, 81, ; Kim K. (2001), Ghrelin and growth hormone (GH) secretagogue receptor (GHSR) mRNA expression in human pituitary adenomas, Clin Endocrinol (Oxf), 54, 759, ; Kim M. (2004), The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes, Mol Endocrinol, 18, 2291, ; Kim S. (2005), Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells, Bone, 37, 359, ; Kojima M. (1999), Ghrelin is a growth hormone-releasing acylated peptide from stomach, Nature, 402, 656, ; Kojima M. (2001), Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor, Trends Endocrinol Metab, 12, 118, ; Korbonits M. (2001), The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors, J Clin Endocrinol Metab, 86, 881, ; Król M. (2010a), Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs, J Appl Genet, 51, 37, ; Król M. (2010b), Transcriptomic "portraits" of canine mammary cancer cell lines with various phenotypes, J Appl Genet, 51, 169, ; Leite-Moreira A. (2007), Physiological, pathological and potential therapeutic roles of ghrelin, Drug Discov Today, 12, 276, ; Leung P. (2007), The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor, Cell Signal, 19, 1011, ; Muccioli G. (2004), Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor, Eur J Pharmacol, 498, 27, ; Murata M. (2002), Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells, J Biol Chem, 277, 5667, ; Nagaya N. (2001), Hemodynamic and hormonal effects of human ghrelin in healthy volunteers, Am J Physiol Regul Integr Comp Physiol, 280. ; Nanzer A. (2004), Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway, Eur J Endocrinol, 151, 233, ; Neary N. (2006), Acylated ghrelin stimulates food intake in the fed and fasted states but desacylated ghrelin has no effect, Gut, 55, 135. ; Ohno T. (2006), Ghrelin does not stimulate gastrointestinal motility and gastric emptying: an experimental study of conscious dogs, Neurogastroenterol Motil, 18, 129, ; Papotti M. (2001), Ghrelin-producing endocrine tumors of the stomach and intestine, J Clin Endocrinol Metab, 86, 5052, ; Peeters T. (2005), Ghrelin: a new player in the control of gastrointestinal fuctions, Gut, 54, 1638, ; Pemberton C. (2008), Biochemistry of ghrelin precursor peptides, Vitam Horm, 77, 13, ; Raghay K. (2006), Ghrelin localization in rat and human thyroid and parathyroid glands and tumours, Histochem Cell Biol, 125, 239, ; Seim I. (2010), Ghrelin gene-related peptides: multi-functional endocrine / autocrine modulators in health an disease, Clin Exp Pharmacol Physiol, 37, 125, ; Takahashi T. (2006), The neuromedin U-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer, Cancer Res, 66, 9408, ; Thompson N. (2004), Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor, Endocrinology, 145, 234, ; Volante M. (2003), Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effect on tumor growth, Am J Pathol, 162, 645, ; Waseem T. (2008), Role of ghrelin axis in colorectal cancer: a novel association, Peptides, 29, 1369, ; Wasko R. (2008), The expression of ghrelin in somatotroph and other types of pituitary adenomas, Neuro Endocrinol Lett, 29, 929. ; Xiang Y. (2011), Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1/2 and PI3K/Akt pathways, Cell Biochem Funct, 29, 149, ; Yeh A. (2005), Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancer, Clin Cancer Res, 11, 8295, ; Yokoyama M. (2005), Influencing the between-feeding and endocrine responses of plasma ghrelin in healthy dogs, Eur J Endocrinol, 152, 155,