Influence of betulinic acid on lymphocyte subsets and humoral immune response in mice
Divisions of PAS
Bauvois B. (2006), Aminopeptidase-N/CD13 (EC 188.8.131.52) inhibitors: chemistry, biological evaluations and therapeutic prospects, Med Res Rev, 26, 88, doi.org/10.1002/med.20044 ; Chandramu C. (2003), Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L, Phytother Res, 17, 129, doi.org/10.1002/ptr.1088 ; Cichewicz R. (2004), Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection, Med Res Rev, 24, 90, doi.org/10.1002/med.10053 ; Dang Z. (2009), Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors, J Med Chem, 52, 7887, doi.org/10.1021/jm9004253 ; Eichenmuller M. (2010), Betulinic acid induces apoptosis and inhibits hedgehog signaling in rhabdomyosarcoma, Br J Cancer, 103, 43, doi.org/10.1038/sj.bjc.6605715 ; Kindt T. (2007), Kuby Immunology, 37. ; Kommera H. (2011), Lupane triterpenoids- betulin and betulinic acid derivatives induce apoptosis in tumor cells, Invest New Drugs, 29, 266, doi.org/10.1007/s10637-009-9358-x ; Look A. (1989), Human myeloid plasma membrane glycoprotein CD 13 (gp150) is identical to aminopeptidase N, J Clin Invest, 83, 1299, doi.org/10.1172/JCI114015 ; Luan Y. (2007), The structure and main functions of aminopeptidase N, Curr Med Chem, 14, 639, doi.org/10.2174/092986707780059571 ; Melzig M. (1998), Betulinic acid inhibits aminopeptidase N activity, Planta Med, 64, 655, doi.org/10.1055/s-2006-957542 ; Mishell R. (1967), Immunization of dissociated spleen cell cultures from normal mice, J Exp Med, 126, 423, doi.org/10.1084/jem.126.3.423 ; Mullauer F. (2010), Betulinic acid, a natural compound with potent anticancer effects, Anticancer Drugs, 21, 215, doi.org/10.1097/CAD.0b013e3283357c62 ; Nakagawa-Goto K. (2009), Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents, Bioorg Med Chem Lett, 19, 3378, doi.org/10.1016/j.bmcl.2009.05.050 ; Recio M. (1995), Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas, Planta Med, 61, 9, doi.org/10.1055/s-2006-957988 ; Schuhly W. (1999), New triterpenoids with antibacterial activity from Zizyphus joazeiro, Planta Med, 65, 740, doi.org/10.1055/s-1999-14054 ; Viji V. (2011), Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells, Br J Pharmacol, 162, 1291, doi.org/10.1111/j.1476-5381.2010.01112.x ; Xu W. (2005), Progress in the development of aminopeptidase N (APN/CD13) inhibitors, Curr Med Chem Anticancer Agents, 5, 281, doi.org/10.2174/1568011053765949 ; Yamashita K. (2002), Effect of three triterpenoids, lupeol, betulin, and betulin acid on the stimu- lus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils, Clin Chim Acta, 325, 91, doi.org/10.1016/S0009-8981(02)00252-8 ; Yi J. (2010), Immunomodulatory effects of betulinic acid from the bark of white birch on mice, J Vet Sci, 11, 305, doi.org/10.4142/jvs.2010.11.4.305 ; Yogeeswari P. (2005), Betulinic acid and its derivatives: a review on their biological properties, Curr Med Chem, 12, 657, doi.org/10.2174/0929867053202214 ; Yun Y. (2003), Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages, Arch Pharm Res, 26, 1087, doi.org/10.1007/BF02994763 ; Zdzisińska B. (2003), Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures, Pol J Pharmacol, 55, 235.