This study investigates the effects of frequency, compression force and Vee angle parameters of High-Frequency Electric Resistance Welding (HF-ERW) process on mechanical properties of API X52 microalloy steel welding joint. Therefore, API X52 microalloy steel sheets having thickness of 8 mm was provided to manufacture pipes with the diameter of 16”. with direct weld seams using the HF-ERW method. During the manufacturing process, frequency values of 150, 200 and 250 kHz, compression forces of 2, 4 and 6 mark and Vee angles of 3°, 5°, and 7° were adopted. After changing the welding parameters, from the welded pipes, tensile and Charpy impact test samples prepared to macroscopically evaluate the weld metal flow and examine the effects of these parameters on mechanical properties of the welded joints. According to the results, it was concluded that frequency of 150 kHz, the compression force of 4 mark and Vee angle of 5° yields best mechanical properties in the HF-ERW joint of API X52 microalloy steel.