CFD modelling of momentum and heat transfer using the Large Eddy Simulation (LES) approach has been presented for a Kenics static mixer. The simulations were performed with the commercial code ANSYS Fluent 15 for turbulent flow of three values of Reynolds number, Re = 5 000, 10 000 and 18 000. The numerical modelling began in the RANS model, where standard k−ε turbulence model and wall functions were used. Then the LES iterations started from the initial velocity and temperature fields obtained in RANS. In LES, the Smagorinsky–Lilly model was used for the sub-grid scale fluctuations along with wall functions for prediction of flow and heat transfer in the near-wall region. The performed numerical study in a Kenics static mixer resulted in highly fluctuating fields of both velocity and temperature. Simulation results were presented and analysed in the form of velocity and temperature contours. In addition, the surface-averaged heat transfer coefficient values for the whole insert length were computed and compared with the literature experimental data. Good compliance of the LES simulation results with the experimental correlation was obtained.