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Abstract

The presence of lipopolysaccharide (LPS) in blood induces an inflammatory response which leads to multiple organ dysfunction and numerous metabolic disorders. Uncontrolled, improper or late intervention may lead to tissue hypoxia, anaerobic glycolysis and a disturbance in the acid -base balance. The effects of LPS-induced toxemia on biological and immunological markers were well studied. However, parameters such as base excess, ions, and acid-base balance were not fully investigated. Therefore, the objective of this study was to examine these blood parameters collectively in LPS-induced inflammatory toxemia in rat’s model. After induction of toxemia by injecting LPS at a rate of 5 mg/kg body weight intravenously, blood was collected from the tail vein of twenty rats and immediately analyzed. After 24 hours, the animals were sacrificed and the blood was collected from the caudal vena cava. The results revealed that the levels of pH, bicarbonate, partial pressure of oxygen, oxygen saturation, Alveolar oxygen, hemoglobin, hematocrit, magnesium (Mg2+), and calcium (Ca2+) were significantly decreased. On the other side, the levels of Base excess blood, Base excess extracellular fluid, partial pressure of carbon dioxide, lactate, Ca2+/Mg2+, potassium, and chloride were significantly increased compared to those found pre toxemia induction. However, sodium level showed no significant change. In conclusion, Acute LPS-toxemia model disturbs acid-base balance, blood gases, and ions. These parameters can be used to monitor human and animal toxemic inflammatory response induced by bacterial LPS conditions to assist in the management of the diagnosed cases.
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Abstract

The article discusses changes in Polish regulations concerning assessment of the climate hazard in underground mines. Currently, the main empirical index representing the heat strain, used in qualification of the workplace to one of the climate hazard levels in Poland is the equivalent climate temperature. This simple heat index allows easy and quick assessment of the climate hazard. To a major extent, simple heat indices have simplifications and are developed for a specific working environments. Currently, the best methods used in evaluation of microclimate conditions in the workplace are those based on the theory of human thermal balance, where the physiological parameters characterising heat strain are body water loss and internal core temperature of the human body. The article describes the results of research on usage of equivalent climate temperature to heat strain evaluation in underground mining excavations. For this purpose, the numerical model of heat exchange between man and his environment was used, taken from PN-EN ISO 7933:2005. The research discussed in this paper has been carried out considering working conditions and clothing insulation in use in underground mines. The analyses performed in the study allowed formulation of conclusions concerning application of the equivalent climate temperature as a criterion of assessment of climate hazards in underground mines.
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