Control of the technological processes of coal enrichment takes place in the presence of wide disturbances. Thus, one of the basic tasks of the coal enrichment process control systems is the stabilization of coal quality parameters at a preset level. An important problem is the choice of the controller which is robust for a variety of disturbances. The tuning of the controller parameters is no less important in the control process . Many methods of tuning the controller use the dynamic characteristics of the controlled process (dynamic model of the controlled object). Based on many studies it was found that the dynamics of many processes of coal enrichment can be represented by a dynamic model with properties of the inertial element with a time delay. The identification of object parameters (including the time constant) in industrial conditions is usually performed during normal operation (with the influence of disturbances) from this reason, determined parameters of the dynamic model may differ from the parameters of the actual process. The control system with controller parameters tuned on the basis of such a model may not satisfy the assumed control quality requirements. In the paper, the analysis of the influence of changes in object model parameters in the course of the controlled value has been carried out. Research on the controller settings calculated according to parameters T and τ were carried out on objects with other parameter values. In the studies, a sensitivity analysis method was used. The sensitivity analysis for the three methods of tuning the PI controller for the coal enrichment processes control systems characterized by dynamic properties of the inertial element with time delay has been presented. Considerations are performed at various parameters of the object on the basis of the response of the control system for a constant value of set point. The assessment of considered tuning methods based on selected indices of control quality have been implemented.
Constantly increasing prevalence of allergic diseases determines the attempts to elaborate the therapeutic strategies activating immune tolerance to particular allergen. Our current research focuses on the antigen-specifi c action of CD8+ suppressor T (Ts) lymphocytes induced in mice by intravenous administration of a high dose of haptenated syngeneic erythrocytes. While the regulatory activity of Ts cells mediated by exosome-delivered miRNA-150 is well defi ned, the mechanism of their induction remained unclear. Th erefore, the current studies investigated the immune eff ects induced in mice by intravenous administration of contact allergens coupled to syngeneic erythrocytes. In mouse models of hapten-induced contact hypersensitivity (CHS) and delayed-type hypersensitivity to ovalbumin, we have shown that intravenous administration of hapten-coupled erythrocytes failed to induce CHS effector cells. Moreover, hapten-induced CHS reaction occurred to be suppressed in mice intravenously administered with syngeneic erythrocytes coupled with protein allergen. Finally, we have demonstrated that intravenously administered allergen induces immune tolerance only when bound to syngeneic erythrocytes, proving that intravenously delivered allergens are deprived of their immunizing properties when coupled with membrane of self cells. Altogether, our current studies suggest that alteration of self cell membrane by allergen binding is enough to induce Ts cell-mediated immune tolerance to nonpathogenic agents, which express a great translational potential in such conditions as allergies and hypersensitivity-related autoimmune disorders.
The present study aimed to determine the role of job components and individual parameters on the raised blood pressure among male workers of textile industry who were exposed to continuous high noise level. Information of all eligible subjects including demographic and individual characteristics, medical history and job characteristics were obtained by direct interview and referring to the medical records. All blood pressure measurements were done using mercury sphygmomanometer in the morning before work. The 8-hours equivalent A-weighted sound pressure level, the level of blood cholesterol and triglyceride, and noise annoyance was determined for each worker. As the result of weighted regression in path analysis (direct effect), only the work shift did not have a significant effect on blood pressure among the studied variables. It can be seen that variables including the level of triglyceride, cholesterol, and noise exposure have the most direct effects on blood pressure. The results of total effects showed that variables, including using the hearing protection device, age, work experience and visibility of sound source, did not have a significant effect on blood pressure. The results of this study indicate that occupational noise exposure alone and combined with other job components and individual parameters is associated with raised blood pressure. However, noise exposure was probably a stronger stressor for increased blood pressure.
Design closure, i.e., adjustment of geometry parameters to boost the performance, is a challenging stage of antenna design process. Given complexity of contemporary structures, reliable parameter tuning requires numerical optimization and can be executed using local algorithms. Yet, EM-driven optimization is a computationally expensive endeavour and reducing its cost is highly desirable. In this paper, a modification of the trust-region gradient search algorithm is proposed for accelerated optimization of antenna structures. The algorithm is based on sparse updates of antenna sensitivities involving various methods that include the Broyden formula used for selected parameters, as well as dimensionality- and convergence-dependent acceptance thresholds which enable additional speedup, and make the procedure easy to tune for various numbers of antenna parameters. Comprehensive verification executed for a set of benchmark antennas delivers consistent results and considerable cost reduction of up to 60 percent with respect to the reference algorithm. Experimental validation is also provided.
High distribution system power-losses are predominantly due to lack of investments in R&D for improving the efficiency of the system and improper planning during installation. Outcomes of this are un-designed extensions of the distributing power lines, the burden on the system components like transformers and overhead (OH) lines/conductors and deficient reactive power supply leading to drop in a system voltage. Distributed generation affects the line power flow and voltage levels on the system equipment. These impacts of distributed generation (DG) may be to improve system efficiency or reduce it depending on the operating environment/conditions of the distribution system and allocation of capacitors. For this purpose, allocating of distributed generation optimally for a given radial distribution system can be useful for the system outlining and improve efficiency. In this paper, a new method is used for optimally allocating the DG units in the radial distribution system to curtail distribution system losses and improve voltage profile. Also, the variation in active power load in the system is considered for effective utilization of DG units. To evidence the effectiveness of the proposed algorithm, computer simulations are carried out in MATLAB software on the IEEE-33 bus system and Vastare practical 116 bus system.