Oxy-fuel combustion (OFC) belongs to one of the three commonly known clean coal technologies for power generation sector and other industry sectors responsible for CO2emissions (e.g., steel or cement production). The OFC capture technology is based on using high-purity oxygen in the combustion process instead of atmospheric air. Therefore flue gases have a high concentration of CO2- Due to the limited adiabatic temperature of combustion some part of CO2must be recycled to the boiler in order to maintain a proper flame temperature. An integrated oxy-fuel combustion power plant constitutes a system consisting of the following technological modules: boiler, steam cycle, air separation unit, cooling water and water treatment system, flue gas quality control system and CO2processing unit. Due to the interconnections between technological modules, energy, exergy and ecological analyses require a system approach. The paper present the system approach based on the 'input-output' method to the analysis of the: direct energy and material consumption, cumulative energy and exergy consumption, system (local and cumulative) exergy losses, and thermoecological cost. Other measures like cumulative degree of perfection or index of sustainable development are also proposed. The paper presents a complex example of the system analysis (from direct energy consumption to thermoecological cost) of an advanced integrated OFC power plant.