Campylobacteriosis is the most common acute bacterial diarrheal disease in our population. It is caused by bacteria of the genus Campylobacter species whose prevalence in the environment and ease of transmission make these infections a serious epidemiological problem. Although the disease usually has a picture of mild self-limiting diarrhea in some cases there is a more severe course with the need for hospital care. Colonization by Campylobacter spp. also plays on of the main role in the pathogenesis of other diseases. The study was conducted using data from the records of 67 patients aged 3 months to 10 years hospitalized for acute diarrheal illness caused by Campylobacter spp. Microbiological culture yielded growth of C. coli in 14 cases and C. jejuni in 52 patients. The isolated pathogens showed significant antibiotic resistance variable depending on the bacterial strain. The least susceptibility to the drugs occurred with erythromycin and was mainly related to C jejuni. In 42 children it was necessary to implement antibiotic therapy during which azithromycin, amoxicillin with clavulanic acid, or Biseptol were used.