The HAp (hydroxyapatite) excellent ion exchange resin and has adsorption properties of heavy metals and organic materials. It is used as an adsorption material and as an organic drug-delivery material due to these characteristics, that are essentially controlled the specific surface area. In this paper, the specific surface area was controlled by adding polymers of polyvinylpyrrolidone (PVP), polystyrene beads (PSB), and polyethylene glycol (PEG). Through the USP process, the HAp powder is able to synthesize into the spherical shape, specific surface area, and pore were controlled by the properties of the polymers.