In this article, an analysis of an innovative system for filtering signals in the audible range (16 Hz - 20 kHz) on programmable logic devices using a filters with a finite impulse response, is presented. Mentioned system was neat combination of software and hardware platform, where in the program layer a multiple programming languages including VHDL, JavaScript, Matlab or HTML were used to create completely useful application. To determine the coefficients of polynomial filters the Matlab Filter Design & Analysis Tool was used. Thanks to the developed graphic layer, a user-friendly interface was created, which allows easily transfer the required coefficients from the computer to the executive system. The practical implementation made on the FPGA platform, specifically on the Altera DE2- 115 development kit with the FPGA Cyclone IV, was compared with simulation realization of Matlab FIR filters. The performed research confirm the effectiveness of filtration in real time with up to 128th order of the filter for both audio channels simultaneously in FPGA-based system.