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Abstract

Most antiseptic agents are intended for use on intact skin, e.g. for hand hygiene or skin preparation before any medical procedure. This paper presents multiple emulsion-based antiseptic agents as formulations for application to body surfaces with modified release rates.
Multiple emulsions with a co-encapsulated antiseptic (phenyl salicylate – salol) and an agent preventing microorganism growth (benzoic acid) were formed in a Couette–Taylor flow apparatus. Results confirmed the possibility of the release kinetics modification while two compounds were encapsulated in the internal droplets of emulsions to control the release rates and time of the dose release. The addition of benzoic acid as a second active compound of the encapsulation process in the internal phase of double O1/W/O2 emulsion reduced the time necessary for the total release of salol triggering a two-step release.
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Bibliography

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Authors and Affiliations

Agnieszka Markowska-Radomska
1
ORCID: ORCID
Ewa Dluska
1
ORCID: ORCID
Agata Metera
1
Maria Wojcieszak
1

  1. Warsaw University of Technology, Faculty of Chemical and Process Engineering, Warynskiego 1, 00-645 Warsaw, Poland
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Abstract

Radiation therapy can be adopted for many cancers, and it can damage healthy tissues and often induces skin lesions (pain/skin irritation/itchiness/dryness/swelling/redness). Many factors influence the adverse effects of radiotherapy, such as radiation dosage, dose frequency and fractioning, the area of skin exposed to radiation and treatment length. In this paper, multiple emulsions with a nonsteroidal anti-inflammatory drug-NSAID (diclofenac) were developed and evaluated for effective topical treatment of skin lesions following anticancer therapy. Multiple emulsions with different drop sizes were prepared in a Couette- Taylor flow contactor. High encapsulation efficiency (> 90%) of diclofenac and high volume packing fraction of the internal droplets (0.54–0.96) were obtained. In addition, due to the presence of a polymer with adhesive properties - sodium carboxymethylcellulose, high emulsion stability (> 60 days) was achieved. The emulsions displayed properties of shearthinning fluids. The release study of diclofenac from a complex emulsion structure confirmed the possibility of modifying the release rates. The effectiveness of emulsion formulations was evaluated based on the viability tests of the fibroblast cell line irradiated with UV dose (15 J/m2) and then treated with the emulsion with diclofenac. The results showed that the multiple emulsion-based formulations might be appropriate carriers for the topical delivery of NSAID drugs.
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Authors and Affiliations

Agnieszka Markowska-Radomska
1
ORCID: ORCID
Patryk Skowroński
1
ORCID: ORCID
Konrad Kosicki
2
ORCID: ORCID
Ewa Dluska
1
ORCID: ORCID

  1. Warsaw University of Technology, Faculty of Chemical and Process Engineering,Waryńskiego 1, 00-645 Warsaw, Poland
  2. University of Warsaw, Faculty of Biology, Institute of Genetics and Biotechnology, AdolfaPawińskiego 5A, 02-106 Warsaw, Poland

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