As a result of experimental data processing, the ratio of alloying elements Кγ' was proposed for the first time, which can be used to assess the mechanical properties, taking into account the complex effect of the main alloy components. The regularities of the influence of the composition on the properties of heat-resistant nickel alloys of equiaxial crystallization are established. It is shown that for multicomponent nickel systems it is possible with a high probability to predict a mismatch, which significantly affects the strength characteristics of alloys of this class. A promising and effective direction in solving the problem of predicting the main characteristics of heat-resistant materials based on nickel is shown.