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Abstract

The interstitial cells known as telocytes have been described in various organs. Their role in the normal physiology and pathogenesis of numerous diseases is well known. They have been described in the context of various diseases (gallstone disease, endometriosis, uterine myoma, hydronephrosis, myocardial infraction, psoriasis, etc.), while their impact on inflammation, involvement in angiogenesis, and repair highlights their part in local homeostasis. What is known about their relationship with the immune system? Their secretomes, genome, immune profiles, contacts with surrounding cells, and specific loca-lization allow us to give a possible explanation for their involvement in pathological pathways. This review aims to present the roles and features of telocytes in the context of intestinal immunity (the largest in our body), in the spleen, their interactions with immunocytes, and their place in stem cell niches.
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Authors and Affiliations

Veronika Aleksandrovych
1
Anna Gil
2
Adrian Poniatowski
1 3

  1. Department of Pathophysiology, Jagiellonian University Medical College, ul. Czysta 18, 31-121 Kraków, Poland
  2. Department of Anatomy, Jagiellonian University Medical College, ul. Kopernika 12, 31-034 Kraków, Poland
  3. Vassar Brothers Medical Center, Department of Medicine, 45 Reade Place, Poughkeepsie, NY, USA

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