The environmental problems caused by the development and utilization of mineral resources have become important factors affecting ecological security. Guizhou is a Chinese province with relatively developed paleoweathered sedimentary bauxite deposits, abundant resource reserves, and a long history of mining. And, the demand for bauxite in Guizhou is expected to continue to grow. However, long-term or unreasonable resource development has produced a series of prominent environmental problems, such as the occupation and destruction of land resources and heavy metal pollution in soil and water bodies. Based on the existing research results in China and abroad, this paper analyzes the current situation, distribution characteristics, and development and utilization of bauxite resources in Guizhou to explain the corresponding environmental impacts. The results show that because of the many types and high concentrations of associated elements in bauxite and the high alkalinity, heavy metal components, and radioactive elements in red mud, the development and utilization of bauxite resources are associated with higher environmental risk. And more impact of bauxite mining on regional biodiversity, soil, air, surface water, and groundwater need to be evaluated. This paper also proposes coping strategies or countermeasures of environmental governance and control to achieve the green, sustainable and high-quality development of bauxite-related industries for meeting future environmental requirements.