In this study, to investigate effects of rhenium addition on the microstructures and mechanical properties, 15Cr-1Mo ODS ferritic steels with rhenium additions were fabricated by the mechanical alloying, hot isostatic pressing, and hot rolling processes. Unremarkable differences on grain morphologies and nano-oxide distributions were estimated in the microstructure observations. However, the ODS ferritic steels with 0.5 wt.% rhenium showed higher tensile and creep strengths at elevated temperature than that without rhenium. It was found that rhenium is very effective to improve the mechanical properties.