The paper presents the research concept and the key questions the team put forward during the implementation of the project entitled ‘Changing innovation processes models: a chance to break out of dependency paths for less developed regions’. In this chapter, research hypotheses, key concepts concerning the theory of path dependence, a review of the enablers and barriers in shaping development paths regarding the individual parts of the research project are indicated. There are also references to public policy proposals that can support the development of the peripheral paths of the peripheral regions as well as future research concepts of this issue.