The structural concept of the dome dates back to the Pantheon in Rome. It is used as the cover of many churches and mosques all around the world. Light solutions, with a well-visible dome-shaped truss skeleton, are often preferred in modern architecture. Base isolation techniques can be adopted to mitigate the seismic effects. This paper aims to investigate the efficiency of different designs for the truss skeleton. To solve the problem, one has to assign the constraints, the materials and the geometry of the dome, its supporting structure and the isolation devices (number, locations, and type). The screening of the effects of different scheme assumptions on structural behaviour provides a better insight into the problem.