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Abstract

Pellagra is a rare disease caused by niacin deficiency or a disruption of its metabolism. Its manifestations are dermatitis with pronounced photosensitivity, gastrointestinal symptoms, and neuropsychiatric ailments. Currently pellagra is developed in people who chronically abuse alcohol or are treated with medications from specific pharmacological groups (immunosuppressive and anti-tuberculosis drugs).
Although the root cause of the disease was established in the mid-twentieth century, a detailed explanation of the processes leading to the development of symptoms has not yet been proposed. They include complex abnormalities at the molecular, metabolic, and immunological levels. Diagnostics is based primarily on the clinical presentation of the disease, while auxiliary tests play secondary role. The low prevalence of the disease, meaning that physicians are unfamiliar with its re-cognition, often leads to delays in diagnosis and appropriate treatment. The therapy is causal and based on administering niacinamide. Failure to implement treatment in the early stages of the disease leads to the patient’s death.
The aim of this literature review is to summarize the current state of knowledge on the pathomechanisms of pellagra, highlighting the clinical implications, and key elements of diagnostic and therapeutic manage-ment that are important in the treatment of pellagra patients.
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Bibliography

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Authors and Affiliations

Przemysław Hałubiec
1
ORCID: ORCID
Monika Leończyk
1
Filip Staszewski
1
Monika Łazarczyk
1
Andrzej Kazimierz Jaworek
1
Anna Wojas-Pelc
1

  1. Department of Dermatology, Jagiellonian University Medical College, Kraków, Poland
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Abstract

The paper presents research results of bond tests in completely concrete encased steel Isection columns made of self-compacting concrete (SCC). The results of push-out tests obtained by elements made of SCC were compared with those elements, which were made of vibrated concrete. The influence of selected factors on resistance to the vertical shear was considered in this study. The analysis of research results shows that the resistance to the vertical shear between steel I-section and SCC concrete depends on distance between stirrups and concrete age. Shrinkage has important influence on interfacial bond forces. The test results were compared with a recommendations given in the Design code – Eurocode 4. This standard can be used only for composite elements made of lightweight and vibrated concrete. In the case of completely concrete encased I-section composite columns the shear resistance after 28 days and after concrete shrinkage was higher than design resistance strength given in the standard. This means that the design value of the shear strength given in the standard should be verified and checked, if it can be applied to elements made of SCC concrete. Further tests should be carried out to determine the value of shear resistance for such elements.
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Authors and Affiliations

Magdalena Szadkowska
1
ORCID: ORCID
Elżbieta Szmigiera
1
ORCID: ORCID

  1. Warsaw University of Technology, Faculty of Civil Engineering, Al. Armii Ludowej 16, 00-637 Warsaw, Poland
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Abstract

Drinking water systems are critical to society. They protect residents from waterborne illnesses and encourage economic success of businesses by providing consistent water supplies to industries and supporting a healthy work force. This paper shows a study on water quality management in a treatment plant (TP) using the Box-Jenkins method. A comparative analysis was carried out between concentrations of water quality parameters, and Colombian legislation and guidelines established by the World Health Organization. We also studied the rainfall influence in relation to variations in water quality supplied by the TP. A correlation analysis between water quality parameters was carried out to identify management parameters during the TP operation. Results showed the usefulness of the Box-Jenkins method for analyzing the TP operation from a weekly timescale (mediumterm), and not from a daily timescale (short-term). This was probably due to significant daily variations in the management parameters of water quality in the TP. The application of a weekly moving average transformation to the daily time series of water quality parameter concentrations significantly decreased the mean absolute percentage error in the forecasts of Box-Jenkins models developed. Box-Jenkins analysis suggested an influence of the water quality parameter concentrations observed in the TP during previous weeks (between 2-3 weeks). This study was probably constituted as a medium-term planning tool in relation to atypical events or contingencies observed during the TP operation. Finally, the findings in this study will be useful for companies or designers of drinking water treatment systems to take operational decisions within the public health framework.

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Authors and Affiliations

E.A. Redondo-Peñuela
H.A. Rondón-Quintana
C.A. Zafra-Mejía
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Abstract

Superheater is for generating superheated steam from the saturated steam from the evaporator outlet. In the case of pulverized coal fired boiler, a relatively small amount of ash causes problems with ash fouling on the heating surfaces, including the superheaters. In the convection pass of the boiler, the flue gas temperature is lower and ash deposits can be loose or sintered. Ash fouling not only reduces heat transfer from the flue gas to the steam, but also is the cause of a higher pressure drop on the flue gas flow path. In the case the pressure drop is greater than the power consumed by the fan increases. If the superheater surfaces are covered with ash than the steam temperature at the outlet of the superheater stages falls, and the flow rates of the water injected into attemperator should be reduced. There is also an increase in flue gas temperature after the different stages of the superheater. Consequently, this leads to a reduction in boiler efficiency. The paper presents the results of computational fluid dynamics simulations of the first stage superheater of both the boiler OP-210M using the commercial software. The temperature distributions of the steam and flue gas along the way they flow together with temperature of the tube walls and temperature of the ash deposits will be determined. The calculated steam temperature is compared with measurement results. Knowledge of these temperatures is of great practical importance because it allows to choose the grade of steel for a given superheater stage. Using the developed model of the superheater to determine its degree of ash fouling in the on-line mode one can control the activation frequency of steam sootblowers.
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Authors and Affiliations

Marcin Trojan
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Abstract

Many researchers have contributed to creating Quantum Key Distribution (QKD) since the first protocol BB84 was proposed in 1984. One of the crucial problems in QKD is to guarantee its security with finite-key lengths by Privacy Amplification (PA). However, finite-key analyses show a trade-off between the security of BB84 and the secure key rates. This study analyses two examples to show concrete trade-offs. Furthermore, even though the QKD keys have been perceived to be arbitrarily secure, this study shows a fundamental limitation in the security of the keys by connecting Leftover Hash Lemma and Guessing Secrecy on the QKD keys.

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Authors and Affiliations

Takehisa Iwakoshi
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Abstract

In this paper the basic methodology of the coupled response-degradation modelling of stochastic dynamical systems is presented

along with the effective analysis of selected problems. First, the general formulation of the problems of stochastic dynamics coupled with the evolution of deterioration process is given. Then some specific degrading oscillatory systems under random excitation are analyzed with a special attention on the systems with fatigue-induced stiffness degradation. Both, the general discussion and the analysis of selected exemplary problems indicate how the reliability of deteriorating stochastic dynamical systems can be assessed.

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Authors and Affiliations

K. Sobczyk

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