Depending on the clinical context, objectives, and treatment requirements, a variety of prosthetic devices capable of artificially reconstructing the dental arches in a manner as customized as possible can be utilized in the treatment of complete edentation. The purpose of this study is to compare the efficacy of general vitamin B12 treatment vs the efficacy of local treatment accomplished through full dentures. The study was performed on a group of patients of Dental Faculty in Iasi.Because cyanocobalamin deficiency is typically treated parenterally, the current study proved the superiority of local treatment with complete dentures obtained through the crosslinked polymerization method, a much easier and less expensive way to perform the same treatment in the same time period.