The aim of the present study was to investigate blood parameters and subsequent fertility in cows with or without increased postpartum polymorphonuclear neutrophil activity. The study was conducted with 15 Brown Swiss cows between 1-3 lactations. Polymorphonuclear neutrophil activities were assessed at 10±4 days before and after parturition. The cows which maintained their phagocytic and oxidative burst activites compared to the prepartum period were classified as control (CON), and cows which increased phagocytic and oxidative burst activites were defined as increased cellular immune response (ICIR) cows. Energy, protein metabolism markers, hepatic enzymes, blood mineral levels and body condition scores were measured at -10±4, 3±2, 10±4 days relative to parturition. Pregnancy rates, the number of inseminations, and calving to pregnancy intervals were evaluated. The mean non-esterified fatty acid (NEFA) and beta -hydroxybutyric acid (BHB) concentrations were lower in ICIR cows. Mean serum calcium (Ca) concentrations were in subclinical hypocalcemia level at day 3±2, 10±4 days postpartum in CON cows. Postpartum immune cell functions and NEFA, BHB concentrations were negatively cor- related. The calving to pregnancy interval were longer in the control cows. However, total preg- nancy rates and the number of insemination in both groups were similar. In conclusion, postpar- tum polymorphonuclear neutrophil activity is affected by periparturient metabolic status. Postpartum energy metabolites negatively affected the postpartum cellular immune response. The increased postpartum polymorphonuclear neutrophil activity at early postpartum period is positively related with subsequent fertility in dairy cows.

Recent papers and studies over the course of last three years have shown that COVID-19 has a negative impact on the speech communication quality between people. This paper presents an influence analysis of the curvature shape of protective transparent shields on the speech signal. Five shields made of the same material and dimensions but with different curvatures were analyzed, from a completely flat to a very curved shield which has the same shape of curvature at its top and bottom and covers the entire face. The influence of the shield is analyzed with two types of experiments – one using dummy head with integrated artificial voice device, and the other using real speakers (female and male actors). It has been shown that usage of protective shields results in a relative increase in the speech signal level, in the frequency range of around 1000 Hz, compared to the situation when protective shields are not used. The relative increase in speech signal levels for large-curvature shields can be up to 8 dB. The possible causes of this phenomenon have been analyzed and examined.

5-fluorouracil (5-FU), which is a commonly used chemotherapy agent exerts undesired cardiac toxicity. Mitochondrial dysfunction is thought to be one of potentially important mechanisms of 5-FU- induced cardiotoxicity. α-ketoglutarate dehydrogenase (α-KGDHC) is the key regulatory enzyme of TCA cycle. The complex consists of multiple copies of three catalytic subunits: α-ketoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). α-KGDHC together with branched chain α-ketoacid dehydrogenase (BCKDHC) and pyruvate dehydrogenase (PDHC), are the members of 2-oxoacid dehydrogenases family that share some structural and functional similarities. Recently, it has been found that 5-FU stimulates BCKDHC in rat’s cardiac muscle. Therefore, we hypothesize that 5-FU modifies α-KGDHC activity and affects cardiac muscle metabolism. The aim of this study was to determine the effect of 5-FU on α-KGDHC activity and protein levels of E1 and E2 subunits of the complex in rat’s cardiac muscle. Wistar male rats were administered with 4 doses of 5-FU, 150 mg/kg b.wt. each (study group) or 0.3% methylcellulose (control group). α-KGDHC activity was assayed spectrophotometrically. The E1 and E2 proteins levels were quantified by Western blot. 5-FU administration resulted in stimulation of myocardial α-KGDHC activity in rats. In addition, E2 protein level increased in response to 5-FU treatment, while the E1 protein level remained unchanged. Up- regulation of α-KGDHC appears to result from change in E2 subunit protein level. However, the effect of 5-FU on factors modifying α-KGDHC activity at post-translational level cannot be excluded.

The Tarnawce I profile, which occurs in the marginal eastern part of the Polish Westem Carpathians, contains loesses representing three last glacial cycles. In this paper we report the results of pollen analysis of the Eemian-Early Glacial pedocomplex and of the Lower plcni-Visrulian loesses with an interstadiał paleosol. The pollen spectra of22 samples were determined. The pollen diagram was divided into 7 local pollen assemblage zones (L PAZ). Interglacial climatic optimum was recorded with the Eemian type of vegetation in the T-4 zone. The coldest conditions occurred during the accumulation of loess, which separates the interglacial and interstadiał soils.

The changes in the paralinguistic (social, economic, cultural) and linguistic sphere influence the quantitative and qualitative changes in a categorically diversified onomastic resource and the communicative flow of its elements on three levels of linguistic contact — nationwide, local and individual. The flow is additionally determined in the sphere of spontaneous everyday communication and in higher communicative functions (official linguistic behaviour). The accumulation of determinants which allow the usage of appropriate names and appellative forms (official and unofficial, e.g. diminutives, feminisms) involves the application of cumulative research methods, including psycho-, socio- and pragmalinguistic description of proper names functioning in communication. The contemporary theory of discourse in its three dimensions — formal, functional and interactional gives this possibility. It also requires the constant specification and standardization of Neoslavonic onomastic terminology.

The article gives a brief presentation of the identity of Septuagint and its history. The issues dealt with are: the literary unity of LXX, its basic terminology and origins, its canon as well as its significance for Judaism and for modern biblical studies.