African swine fever (ASF) is an acute, hemorrhagic, and devastating viral infectious disease that causes important economic losses to the swine industry. Currently, there are no effective vaccines or drugs available. Epigenetic mechanisms, especially cytosine methylation of cytosine- -phosphate-guanine (CpG) islands, have a significant impact on the life cycle of several viruses. Hence, drugs targeting DNA methylation may potentially be used for the treatment of ASF. Here, we selected the inner core, core shell, inner membrane, capsid, and external envelope membrane, to analyze the characteristics of CpG islands in the ASF virus (ASFV) genomes. Furthermore, we analyzed the promoters and CpG islands in the upstream regions of these genes. Results showed that the CpG islands of seven genes were conserved in the genomes of two genotype of ASFV strains, whereas the CpG islands of other genes were relatively conserved (ASFV strains differed mainly in the quantity of CpG islands). The different distribution of CpG islands in the genomes of different ASFV strains may affect their methylation status, which may in turn affect the regulation of viral gene expression, leading to different clinical outcomes. In addition, the predicted promoter regions based on the upstream sequences of most genes overlapped with CpG island positions. Methylation of the binding sites of the promoter regions inhibits the binding of the transcription factors to the promoters, thus inhibiting the activation of the promoters and limiting the synthesis of viral proteins. The results of this study provide a basis for exploring new antiviral therapeutic strategies from an epigenetic perspective.

In this work we present the design and the manufacturing processes, as well as the acoustics standardization tests, of an acoustic barrier formed by a set of multi-phenomena cylindrical scatterers. Periodic arrangements of acoustic scatterers embedded in a fluid medium with different physical properties are usually called Sonic Crystals. The multiple scattering of waves inside these structures leads to attenuation bands related to the periodicity of the structure by means of Bragg scattering. In order to design the acoustic barrier, two strategies have been used: First, the arrangement of scatterers is based on fractal geometries to maximize the Bragg scattering; second, multi-phenomena scatterers with several noise control mechanisms, as resonances or absorption, are designed and used to construct the periodic array. The acoustic barrier reported in this work provides a high technological solution in the field of noise control.

The chaotic phenomena of coronary artery systems are hazardous to health and may induce illness development. From the perspective of engineering, the potential harm can be eliminated by synchronizing chaotic coronary artery systems with a normal one. This paper investigates the chaos synchronization problem in light of the methodology of sliding mode control (SMC). Firstly, the nonlinear dynamics of coronary artery systems are presented. Since the coronary artery systems suffer from uncertainties, the technique of derivative-integral terminal SMC is employed to achieve the chaos synchronization task. The stability of such a control system is proven in the sense of Lyapunov. To verify the feasibility and effectiveness of the proposed method, some simulation results are illustrated in comparison with a benchmark.