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Abstract

This study aims to determine the potential of Kebar grass extract in reducing the impact of liver damage in mice offspring ( Mus musculus) from parent exposed to carbofuran during lactation period. 42 lactation mice ( Mus musculus) used in the study were divided into seven groups, each group consisting of six mice. Carbofuran, Kebar grass extract, and vitamin C are administered orally on days 1 to 14 after birth. This group consisted of K (aquadest), P1 (carbofuran 1/4 LD50 0.0125 mg/day), P2 (carbofuran 1/8 LD50 0.00625 mg/day), P3 (Kebar grass extract 3.375 mg (0.2 ml) + carbofuran 1/4 LD50), P4 (Kebar grass extract 3.375 mg (0.2 ml) + carbofuran 1/8 LD50), P5 (vitamin C 5 mg (0.2 ml) + carbofuran 1/4 LD50), and P6 (vitamin C 5 mg (0.2 ml) + carbofuran 1/8 LD50). On the 15th day after birth, mice were sacrified and their liver taken for microscopic examination with hematoxilin and eosin staining. The scoring data were analyzed using Kruskal-Wallis and Mann-Whitney test. The result showed significant different (p<0.05) among the treatment groups. Mean of P4 in degeration is (1.13), necrosis (1.13) and inflamation (0.73), while the mean of P6 in degeneration is (2.20), necrosis (2.73) and inflamation (1.93). The conclusion of this research is giving Kebar grass extract is more effective in reducing degeneration, necrosis and inflammatory cell’s infiltration than vitamin C in in mice offspring ( Mus musculus) from parent exposed to carbofuran during lactation period.
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Authors and Affiliations

N.A. Yulitasari
1
S. Hidanah
1
Widjiati
1
V.F. Hendrawan
2
E.M. Luqman
1

  1. Department of Veterinary Science Faculty of Veterinary Medicine Universitas Airlangga Kampus C Unair, Jalan Mulyorejo Surabaya 60115 Indonesia
  2. Department of Animal Reproduction Faculty of Veterinary Medicine, Universitas Brawijaya, Jl. MT. Haryono No.169, Ketawanggede, Lowokwaru, Kota Malang, 65144 Indonesia
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Abstract

The technical requirements for the determination of physical parameters of vibration isolating material have not been standardized in Europe and Poland yet, which significantly hinders the ability to compare vibration isolating materials offered on the market. Therefore, there is a need for establishing a norm that could be applied both for the determination of the physico-mechanical properties of elastic vibration isolation elements in rail transport for domestic and foreign producers as well as in their selection for application in a specific vibration isolation system. The paper presents a proposal to standardize the methodology of the estimation of vibration isolation materials physical parameters authorized for use in vibration isolation systems used in rail transport. Methodology for measuring the physico-mechanical parameters of vibration isolating material presented in the paper forms uniform test procedure developed based on a fragmentary norms for flexible materials testing. The use of the proposed research methodology enables the creation of a unified database of elastic materials which parameters will be easy to compare, and choice between them will become easier for designers of vibration isolation systems used in rail transport.

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Authors and Affiliations

Jarosław Bednarz

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