This chapter provides a quantitative analysis to identify weak regions that have changed the innovation model. The analysis was carried out at the beginning of the project, in 2015, when only data on GDP per capita for the EU regions was available until 2011. It was designed to identify regions that have changed the innovation model for their in-depth qualitative research, that is to prepare case studies. To indicate the development paths of European regions, a comparative analysis of means was prepared. Innovation models and their change were indicated by clusters analysis. In addition, an econometric analysis of growth factors in the EU regions covering data on GDP per capita in the EU regions in 2014 was carried out in 2017.