Search results

Filters

  • Journals
  • Keywords
  • Date

Search results

Number of results: 2
items per page: 25 50 75
Sort by:
Download PDF Download RIS Download Bibtex

Abstract

Wacław Tadeusz Szybalski (1921–2020) was born in the city of Lwów. Gradueted from School of Chemistry of Technical University of Lwów (Politechnika Lwowska). In 1945 he obtained diploma of chemical engineering from Silesian University of Technology in Gliwice and PhD in 1949 from Gdańsk University of Technology. He left Poland in 1949, first for Denmark and later USA. From 1951–1955 Wacław Szybalski joined the famous Cold Spring Harbor Laboratory, NY, as a Staff Member. From 1960 to 2003 he has position of Professor of Oncology at the McArdle Laboratory for Cancer Research of the University of Wisconsin-Madison, USA. Prof. Wacław Szybalski published over 260 scientific papers, covering many areas of biology, including bacterial genetics, mechanisms of drug resistance and radiosensitization, mutagenesis, multi-drug therapy, molecular biology of bacteriophages, particularly phage lambda, genetic engineering, gene therapy, synthetic biology and DNA biochemistry/sequencing. Prof. Wacław Szybalski retired in 2003, and held the rank of Emeritus Professor of Oncology and of Genetics since then. During all years in USA Wacław Szybalski relations with Poland, especially Gdańsk remained very strong. He was a Mentor of several Polish postdocs. Prof. Wacław Szybalski received many science awards over the years, was a Foreign Member of the Polish Academy of Sciences and Polish Academy of Art and Sciences. In 2011, he received the highest honor awarded in Poland, becoming a Knight of the Order of Polonia Restituta, First Class, presented by President of Poland Bronisław Komorowski. He has also received five honorary doctorates from leading universities in Poland.
Go to article

Authors and Affiliations

Ewa Łojkowska
1 2

  1. Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i GUMed
  2. Fundacja Profesora Wacława Szybalskiego
Download PDF Download RIS Download Bibtex

Abstract

Steroidal saponins isolated from many plant species belonging to Monocotyledones display potent cytotoxic activity towards many human tumor cells. We examined the cytotoxic effects of crude Paris quadrifolia extract for the first time, testing isolated saponin-rich fractions against four different human cell lines using the [(3-(4,5-dimethylthiazol-2-yl)]-2,5-diphenyltetrazolium bromide (MTT) assay. Cytotoxic activity was tested against human promyelocytic leukemia (HL-60) cells, human cervical adenocarcinoma (HeLa) cells and human breast cancer (MDA-MB-468) cells. Human skin fibroblasts were used as non-neoplastic control cells. Our results show significant activity of the weakly water-soluble solid residue and butanolic fraction against HL-60 and HeLa cells. The solid residue exerted cytotoxicity against all tested cell lines.

Go to article

Authors and Affiliations

Justyna Stefanowicz-Hajduk
Anna Kawiak
Jerzy Gajdus
J. Ochocka
Monika Paszkiewicz
Piotr Stepnowski
Ewa Łojkowska

This page uses 'cookies'. Learn more