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Abstract

In recent years there have been a growing number of reports on applying viruses in oncological treatment. In the present study, we demonstrated for the first time that animal virus EHV-1 productively replicates in the human adenocarcinoma cell line (A549) without the need for adaptation. Real-time PCR analysis and immunofluorescence assay showed that EHV-1 could infect and causes lysis of human lung cancer cells. According to our results, we can assume that EHV-1 has oncolytic potential.
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Bibliography


Chodkowski M, Cymerys J, Słońska A, Bańbura M (2017) Oncolytic animal viruses and their applications in anti-cancer therapies. Med Weter 73: 4-9.

Courchesne MJ, White MC, Stanfield BA, Frampton AR (2012) Equine herpesvirus type 1-mediated oncolysis of human glioblastoma multi-forme cells. J Virol 86: 2882-2886.

Cymerys J, Dzieciątkowski T, Słońska A, Bierla J, Tucholska A, Chmielewska A, Golke A, Bańbura MW (2010) Equine herpesvirus type 1 (EHV-1) replication in primary murine neurons culture. Pol J Vet Sci 13: 701-708.

Cymerys J, Słońska A, Brzezicka J, Tucholska A, Chmielewska A, Rola J, Bańbura MW (2016) Replication kinetics of neuropathogenic and non-neuropathogenic equine herpesvirus type 1 (EHV-1) strains in primary murine neurons and ED cell line. Pol J Vet Sci 19: 777-784.

Drukker M, Katz G, Urbach A, Schuldiner M, Markel G, Itskovitz-Eldor J, Benvenisty N (2002) Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Nat Acad Sci 99: 9864-9869.

Liu BL, Robinson M, Han ZQ (2003) ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties. Gene Ther 10: 292-303.

Słońska A, Cymerys J, Godlewski MM, Bańbura MW (2016) Application of scanning cytometry and confocal-microscopy-based image analysis for investigation the role of cytoskeletal elements during equine herpesvirus type 1 (EHV-1) infection of primary murine neurons. J Virol Met 237:1-9.

White MC, Frampton AR Jr (2013) The histone deacetylase inhibitor valproic acid enhances equine herpesvirus type 1 (EHV-1)-mediated oncolysis of human glioma cells. Cancer Gene Ther 20: 88-93.
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Authors and Affiliations

M. Chodkowski
1 2
A. Słońska
1
M. Bartak
1
M.W. Bańbura
1
J. Cymerys
1

  1. Department of Preclinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
  2. Laboratory of Nanobiology and Biomaterials, Military Institute of Hygiene and Epidemiology, Kozielska 4 Warsaw, Poland
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Abstract

In the present study, the influence of the infection with equine herpesvirus type 1 (non-neuropathogenic and neuropathogenic strains of EHV-1) on the morphology and distribution of mitochondrial network in equine dermal cell line was investigated. Our results indicate that EHV-1-infection caused changes in the mitochondrial morphology manifested mostly by fission and reactive oxygen species generation.

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Authors and Affiliations

M. Bartak
M. Chodkowski
A. Słońska
M.W. Bańbura
J. Cymerys

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