Search results

Filters

  • Journals
  • Authors
  • Keywords
  • Date
  • Type

Search results

Number of results: 3
items per page: 25 50 75
Sort by:
Download PDF Download RIS Download Bibtex

Abstract

Lyme disease is an emerging problem in Poland. Analysis has been undertaken of the medical documentation of 86 patients hospitalized in the Infectious Diseases Department, University Hospital in Cracow in 2013–2016, suspected of Lyme arthritis. It has especially considered medical history including potential exposure to the infection, detailed characteristics of the symptoms, diagnostic challenges and results of the treatment. Only some patients had a history of erythema migrans and not all of them recalled tick-bite. The majority of the patients had affected large joints, especially knee joints, and polyarthritis was rarely observed. Symptoms were resolved completely or partially after antibiotic treatment in most patients. The diagnosis of Lyme arthritis in areas endemic for Lyme disease is still a diagnostic challenge in patients with other rheumatic diseases, including osteoarthritis.

Go to article

Authors and Affiliations

Katarzyna Stażyk
Jacek Czepiel
Martyna Gumulska
Aleksander Garlicki
Grażyna Biesiada
Download PDF Download RIS Download Bibtex

Abstract

Introduction: Clostridium difficile (C. difficile) is a Gram-positive, anaerobic rod-shaped bacteria, widely spread in the human environment. In the last decade, the frequency and severity of Clostridium difficile infection (CDI) have been increasing, making this particular disease one of the most significant nosocomial infections. The aim of our study was an analysis of CDI risk factors, its course and consequences.

Materials and Methods: Medical documentation of the patients treated for CDI in the University Hospital in Cracow and St Anne’s Hospital in Miechów has been analysed. The analysis focused on epidemiological data, blood parameters, comorbidities, recurrence rate, and complication rate (deaths included). As part of risk factors analysis, antibiotic use or hospitalisation in a period of 3 months before the episode of infection was considered relevant. Blood tests have been performed using routinely employed, standard methods.

Results: We evaluated data of 168 people infected with C. difficile, out of which there were 102 women (61%) and 66 men (39%). Th e median age of the patients was 74 years for the entire population with 76 years for women and 71 years for male patients. One hundred thirteen people (67%) had been previously hospitalised, and 5 person was a pensioner of a nursing home. 99 people (59%) were treated with antibiotics within 3 months before the first episode of infection. An average length of the hospital stay because of CDI was 11 days. One hundred thirty persons (77%) experienced only 1 episode whereas 38 people (23%) had more than 1 episode of infection. The person with the largest number of recurrences had 9 of them.

Conclusions: The development of CDI is an increasing problem in a group of hospitalised persons, particularly of an old age. The general use of beta-lactam antibiotics is the cause of a larger number of infections with C. diffi cile. Vast majority of patients have had at least one typical risk factor of CDI development.

Go to article

Authors and Affiliations

Mirosław Dróżdż
Grażyna Biesiada
Anna Piątek
Magdalena Świstek
Mateusz Michalak
Katarzyna Stażyk
Aleksander Garlicki
Jacek Czepiel
Download PDF Download RIS Download Bibtex

Abstract

I n t r o d u c t i o n: Fecal calprotectin (FC) rises significantly in intestinal inflammation accompanied by neutrophil activation — such as Clostridium diffi cile infection (CDI). The aim of the study was to evaluate the benefi t of FC testing in assessing the severity of CDI.

Ma t e r i a l s a n d M e t h o d s: The study group included 76 patients with CDI hospitalized in the Jagiellonian University Hospital in Krakow from July 2017 till January 2018. FC levels were measured using an EIA (Enzyme Immunoassay). Demographic, clinical information and blood tests were recorded using standardized data collection forms. The selection of patients into non-severe and severe groups was carried out in accordance with the ESCMID criteria (European Society of Clinical Microbiology and Infectious Diseases) and some modifications to those criteria were proposed.

R e s u l t s: The studied population included 76 patients (39 men and 37 women) with CDI aged from 24 to 98 years (mean: 72). Median calprotectin level was 739 (Q25–Q75: 612–799 μg/g), characteristic of patients with colitis. A statistically signifi cant diff erence in FC concentration in patients with severe vs non-severe CDI was observed (severe — 770 vs non-severe — 659 μg/g, p = 0.009). FC directly correlated with platelets level; however, no correlation between FC level and the blood parameters prognostic for CDI (leukocyte, neutrophil count, albumin, creatinine levels) was found.

C o n c l u s i o n: FC level is an indication of ongoing intestinal inflammation in CDI patients. FC level significantly correlated with CDI severity, which demonstrates that FC could serve as a predictive marker for assessing CDI severity.

Go to article

Authors and Affiliations

Mirosław Dróżdż
Grażyna Biesiada
Hanna Pituch
Dorota Wultańska
Piotr Obuch-Woszczatyński
Michał Piotrowski
Jolanta Kędzierska
Mateusz Michalak
Aleksander Garlicki
Jacek Czepiel

This page uses 'cookies'. Learn more