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Abstract

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder diagnosed on the basis of Rome IV criteria. Stress is an important contributor to the development of IBS symptoms, while personality, perceived self-efficacy, resilience, and coping strategies may be indirectly involved in the modulation of the body’s response to various stressors. The aim of this study was to assess the effect of selected personality traits and stress with IBS symptoms. We enrolled 129 participants (59 men and 70 women) aged from 18 to 61 years. The study group included 94 patients with IBS, while the control group comprised 35 participants without a diagnosed psychoso-matic disorder and chronic comorbidities. Participants were assessed using a self-designed questionnaire as well as the Coping Inventory for Stressful Situations, NEO-Five Factor Inventory, 25-item Resilience Coping Scale (Skala Pomiaru Prężności — SPP-25), and General Self-Efficacy Scale. We observed a significant effect of personality, perceived self-efficacy, resilience, and coping strategies in patients with IBS. Moreover, stress was shown to be associated with disease severity, while the type of a coping strategy was related to the frequency of symptoms. The groups differed in terms of personality traits such as resilience, self-efficacy, extraversion, and neuroticism. Our study confirms the significant effect of personality traits and coping strategies in patients with IBS.

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Authors and Affiliations

Agnieszka Dąbek-Drobny
Tomasz Mach
Małgorzata Zwolińska-Wcisło
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Abstract

Introduction: Inflammatory bowel disease (IBD) represents a group of chronic inflamma-tory disorders characterized by dysbiosis and altered short-chain fatty acid (SCFA) level. The association between individual SCFA levels and cytokine levels is unknown.
Objectives: We aimed to determine the fecal SCFA levels in patients with IBD in relation to disease severity and the serum levels of pro- and anti-inflammatory cytokines.
Patients and Methods: The study included 61 patients with IBD (inactive, 22; active, 39) and 16 controls. Fecal levels of organic acids (acetic, lactic, propionic, butyric, isovaleric, isobutyric, and valeric), serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), IL-17, and IL-22, complete blood count and C-reactive protein (CRP) were measured.
Results: Patients with active IBD had reduced butyric, acetic, valeric, and isovaleric acid levels and elevated lactic acid levels in stool. Hemoglobin levels were positively correlated with the levels of acetic and butyric acids ( R = 0.266 and R = 0.346, respectively; P <0.05). In addition, CRP levels were inversely correlated with butyric acid levels ( R = –0.573; P <0.05). Higher serum TNF-α levels were observed in patients with active IBD compared with controls (6.64 pg/ml vs 2.05 pg/ml, P <0.05). No relationship was noted between the SCFA profile and cytokine levels.
Conclusions: The study showed that determination of SCFA levels can be used to evaluate the activity of IBD. The relationship between individual SCFA and cytokine levels seems to be complex and requires further studies.
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Authors and Affiliations

Olga Kaczmarczyk
1
Agnieszka Dąbek-Drobny
2
Michał Woźniakiewicz
3
Paweł Paśko
4
Justyna Dobrowolska-Iwanek
4
Aneta Woźniakiewicz
3
Aneta Targosz
5
Agata Ptak-Belowska
5
Agnieszka Piątek-Guziewicz
1
Kacper Wcisło
6
Paweł Zagrodzki
4
Małgorzata Zwolińska-Wcisło
1 2

  1. Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland
  2. Unit of Clinical Dietetics, Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland
  3. Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Kraków, Poland
  4. Department of Food Chemistry and Nutrition, Jagiellonian University Medical College, Kraków, Poland
  5. Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  6. Department of Pathomorphology, University Hospital, Kraków, Poland

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