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Number of results: 6
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Abstract

The aim of the study was to choose and validate the tool(s) to predict the number of hospitalized patients by testing three predictive algorithms: a linear regression model, Auto-Regressive Moving Average (ARMA) model, and Generalized Auto-Regressive Conditional Heteroskedasticity (GARCH) model. The study used data from the collection of data on infl ammatory bowel diseases (IBD) from the public database of the National Health Fund for the years 2009–2017, data recalculation taking into account the population of provinces and the country in particular years, and prediction making for the number of patients who would require hospitalization in 2017. Th e anticipated numbers were compared with real data and percentage prediction errors were calculated. Results of prediction for 2017 indicated the number of hospitalizations for Crohn’s disease (CD) and ulcerative colitis (UC) at 17 and 16 respectively per 100,000 persons and 72 per 100,000 persons for all IBD cases. Th e actual outcomes were 21 for both CD and UC (81% and 75% accuracy of prediction, respectively), and 99 for all IBD cases (73% accuracy). The prediction results do not diff er signifi cantly from the actual outcome, this means that the prediction tool (in the form of a linear regression) actually gives good results. Our study showed that the newly developed tool may be used to predict with good enough accuracy the number of patients hospitalized due to IBD in order to organize appropriate therapeutic resources.

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Authors and Affiliations

Norbert Tuśnio
Jakub Fichna
Przemysław Nowakowski
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Abstract

Irritable bowel syndrome (IBS) is a multifactorial gastrointestinal disorder with still not fully understood pathogenesis. At first, the treatment of IBS was mainly focused on alleviating symptoms (with the use of laxatives, anti-diarrheals, anti-spasmodics and painkillers) and then became more specific by targeting discovered pathways responsible for proper functioning of the gastrointestinal system, for in-stance: 5HT3, 5HT4, cannabinoid and opioid receptors, guanylyl cyclase C, chloride channels and sodium- hydrogen exchanger. Nowadays, there is a growing number of experimental IBS treatment strategies and in this article we discuss these novel and therapeutic options in IBS, their efficacy and future perspectives.
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Authors and Affiliations

Jakub Włodarczyk
1
ORCID: ORCID
Patrycja Szałwińska
1
Anna Waśniewska
1 2
Jakub Fichna
1

  1. Department of Biochemistry, Medical University of Lodz, Poland
  2. Department of Normal and Clinical Anatomy, Medical University of Lodz, Poland
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Abstract

Layers of silver particles are used in the studies on pathophysiology and treatment of diseases, both in pre-clinical and clinical conditions. Silver layers can be formed using different techniques and on different substrates. Deposition by magnetron sputtering on glass beads was used in this study. Silver absorption by the body was estimated by calculating the difference in thickness of the silver nanolayer deposited on a bead and measured before and after application of the bead in an animal model of gastrointestinal inflammation. Recommendations for the minimal thickness of silver nanolayer deposited on glass beads were worked out for further studies.

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Authors and Affiliations

Krzysztof Siczek
Wojciech Pawlak
Hubert Zatorski
Jakub Fichna

Authors and Affiliations

Jakub Fichna
Konrad Osajda
Aneta Pieniądz
Bartłomiej Skowron
ORCID: ORCID

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