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Abstract

I n t r o d u c t i o n: Stress is an ubiquitous phenomenon in the modern world and one of the major risk factors for cardiovascular disease. Th e aim of our study was to evaluate the effect of various acute stress stimuli on autonomic nervous system (ANS) activity, assessed on the basis of heart rate (HRV) and blood pressure (BPV) variability analysis.

Ma t e r i a l s a n d M e t h o d s: The study included 15 healthy volunteers: 9 women, 6 men aged 20– 30 years (23.3 ± 1.8). ANS activity was assessed by HRV and BPV measurement using Task Force Monitor 3040 (CNSystems, Austria). ECG registration and Blood Pressure (BP) measurement was done 10 minutes at rest, 10 minutes aft er the stress stimulus (sound signal, acoustic startle, frequency 1100 Hz, duration 0.5 sec, at the intensity 95 dB) and 10 minutes aft er the cold pressor test. The cold pressor test (CPT) was done by placing the person’s hand by wrist in ice water (0–4°C) for 120 s.

R e s u l t s: Every kind of stress stimulation (acoustic startle; the CPT) caused changes of HRV indicator values. The time domain HRV analysis parameters (pNN50, RMSSD) decreased aft er acoustic stress and the CPT, but were signifi cantly lower after the CPT. In frequency domain HRV analysis, significant differences were observed only aft er the CPT: (LF-RRI 921.23 ms2 vs. 700.09 ms2; p = 0.009 and HF-RRI 820.75 ms2 vs. 659.52 ms2; p = 0.002). The decrease of LF-RRI and HF-RRI value aft er the CPT was significantly higher than after the acoustic startle (LF-RRI 34% vs. 0.4%, p = 0.022; HF-RRI 19.7% vs. 7% ms2, p = 0.011). The decreased value of the LF and HF components of HRV analysis are indicative of sympathetic activation. Nonlinear analysis of HRV indicated a significant decrease in the Poincare plot SD1 (p = 0.039) and an increase of DFAα2 (p = 0.001) in response to the CPT stress stimulation. Th e systolic BPV parameter LF/HF-sBP increased signifi cantly aft er the CPT (2.84 vs. 3.31; p = 0.019) and was higher than aft er the acoustic startle (3.31 vs. 3.06; p = 0.035). Signifi cantly higher values of diastolic BP (67.17 ± 8.10 vs. 69.65 ± 9.94 mmHg, p = 0.038) and median BP (83.39 ± 8.65 vs. 85.30 ± 10.20 mmHg, p = 0.039) were observed in the CPT group than in the acoustic startle group.

C on c l u s i o n s: Th e Cold Pressor Test has a greater stimulatory eff ect on the sympathetic autonomic system in comparison to the unexpected acoustic startle stress. Regardless of whether the stimulation originates from the central nervous system (acoustic startle) or the peripheral nervous system (CPT), the final response is demonstrated by an increase in the low frequency components of blood pressure variability and a decrease in the low and high frequency components of heart rate variability.

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Authors and Affiliations

Jarosław Jarczewski
Agata Furgała
Aleksandra Winiarska
Mateusz Kaczmarczyk
Adrian Poniatowski
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Abstract

Microvascular angina (MVA) is a condition characterized by the presence of angina-like chest pain, a positive response to exercise stress tests, and no significant stenosis of coronary arteries in coronary angiography, with absence of any other specific cardiac diseases. The etiology of this syndrome is still not known and it is probably multifactorial. Coronary microvascular dysfunction is proposed as the main pathophysiological mechanism in the development of MVA. Altered somatic and visceral pain perception and autonomic imbalance, in addition to myocardial ischemia, has been observed in subjects with MVA, involving dynamic variations in the vasomotor tone of coronary microcirculation with consequent tran-sient ischemic episodes. Other theories suggest that MVA may be a result of a chronic inflammatory state in the body that can negatively influence the endothelium or a local imbalance of factors regulating its function. This article presents the latest information about the epidemiology, diagnostics, etiopathogen-esis, prognosis, and treatment of patients with MVA.
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Authors and Affiliations

Jarosław Jarczewski
1
Aleksandra Jarczewska
1
Andrzej Boryczko
1
Adrian Poniatowski
1
Agata Furgała
1
Andrzej Surdacki
2
Krzysztof Gil
1

  1. Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
  2. Second Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland
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Abstract

B a c k g r o u n d: Stress is a major risk factor for cardiovascular (CV) disease. We hypothesized that past strong experiences might modulate acute CV autonomic responses to an unexpected acoustic stimulus.
A i m: The study’s aim was to compare acute CV autonomic responses to acoustic stress between students with and without a past strong experience associated with the acoustic stimulus.
M a t e r i a l s and M e t h o d s: Twenty five healthy young volunteers — medical and non-medical students — were included in the study. CV hemodynamic parameters, heart rate (HR), and blood pressure (BP) variability were assessed for 10 min at rest and for 10 min after two different acoustic stimuli: a standard sound signal and a specific sound signal used during a practical anatomy exam (so-called “pins”).
R e s u l t s: Both sounds stimulated the autonomic nervous system. The “pins” signal caused a stronger increase in HR in medical students (69 ± 10 vs. 73 ± 13 bpm, p = 0.004) when compared to non-medical students (69 ± 6 vs. 70 ± 10, p = 0.695). Rises in diastolic BP, observed 15 seconds after sound stressors, were more pronounced after the “pins” sound than after the standard sound signal only in medical students (3.1% and 1.4% vs. 3% and 4.4%), which was also reflected by low-frequency diastolic BP variability (medical students: 6.2 ± 1.6 vs. 4.1 ± 0.8 ms2, p = 0.04; non-medical students: 6.0 ± 4.3 vs. 4.1 ± 2.6 ms2, p = 0.06).
C o n c l u s i o n s: The “pins” sound, which medical students remembered from their anatomy practical exam, provoked greater sympathetic activity in the medical student group than in their non-medical peers. Thus, past strong experiences modulate CV autonomic responses to acute acoustic stress.
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Bibliography

1. Florian J.P., Simmons E.E., Chon K.H., Faes L., Shykoff B.E.: Cardiovascular and autonomic responses to physiological stressors before and after six hours of water immersion. J Appl Physiol (1985). 2013 Nov 1; 115 (9): 1275–1289.
2. Björ B., Burström L., Karlsson M., Nilsson T., Näslund U., Wiklund U.: Acute effects on heart rate variability when exposed to hand transmitted vibration and noise. Int Arch Occup Environ Health. 2007 Nov; 81 (2): 193–199.
3. Koelsch S., Jäncke L.: Music and the heart. Eur Heart J. 2015 Nov 21; 36 (44): 3043– 3049.
4. Ekuni D., Tomofuji T., Takeuchi N., Morita M.: Gum chewing modulates heart rate variability under noise stress. Acta Odontol Scand. 2012 Dec; 70 (6): 491–496.
5. Cheng T.H., Tsai C.G.: Female Listeners’ Autonomic Responses to Dramatic Shifts Between Loud and Soft Music/Sound Passages: A Study of Heavy Metal Songs. Front Psychol. 2016 Feb 17; 7: 182.
6. Walker E.D., Brammer A., Cherniack M.G., Laden F., Cavallari J.M.: Cardiovascular and stress responses to short-term noise exposures-A panel study in healthy males. Environ Res. 2016 Oct; 150: 391–397.
7. Berntson G.G., Bigger J.T. Jr, Eckberg D.L., et al.: Heart rate variability: origins, methods, and interpretive caveats. Psychophysiology. 1997; Nov; 34 (6): 623–648.
8. Cygankiewicz I., Zareba W.: Heart rate variability. Handb Clin Neurol. 2013; 117: 379–393.
9. Sacha J.: Interaction between heart rate and heart rate variability. Ann Noninvasive Electrocardiol. 2014 May; 19 (3): 207–216.
10. van Ravenswaaij-Arts C.M., Kollée L.A., Hopman J.C., Stoelinga G.B., van Geijn H.P.: Heart rate variability. Ann Intern Med. 1993 Mar 15; 118 (6): 436–447.
11. Buccelletti F., Bocci M.G., Gilardi E., et al.: Linear and nonlinear heart rate variability indexes in clinical practice. Comput Math Methods Med. 2012; 2012: 219080.
12. Goldberger A.L.: Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside. Lancet. 1996; 347: 1312–1314.
13. Sassi R., Cerutti S., Lombardi F., et al.: Advances in heart rate variability signal analysis: joint position statement by the e-Cardiology ESC Working Group and the European Heart Rhythm Association co-endorsed by the Asia Pacific Heart Rhythm Society. Europace. 2015 Sep; 17 (9): 1341–1353.
14. Adlan A.M., Veldhuijzen van Zanten J.J.C.S., Lip G.Y.H., Paton J.F.R., Kitas G.D., Fisher J.P.: Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men. J Physiol. 2018; 596: 4847–4861.
15. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation. 1996 Mar 1; 93 (5): 1043– 1065.
16. Iyengar N., Peng C.K., Morin R., Goldberger A.L., Lipsitz L.A.: Age-related alterations in the fractal scaling of cardiac interbeat interval dynamics. Am J Physiol. 1996 Oct; 271 (4 Pt 2): R1078-84.
17. Baek H.J., Cho C.H., Cho J., Woo J.M.: Reliability of ultra-short-term analysis as a surrogate of standard 5-min analysis of heart rate variability. Telemed J E Health. 2015; 21 (5): 404–414.
18. Przybylska-Felus M., Furgala A., Zwolinska-Wcislo M., et al.: Disturbances of autonomic nervous system activity and diminished response to stress in patients with celiac disease. J Physiol Pharmacol. 2014 Dec; 65 (6): 833–841.
19. de Castro B.C., Guida H.L., Roque A.L., et al.: Auditory stimulation with music influences the geometric indices of heart rate variability in response to the postural change maneuver. Noise Health. 2014; Jan–Feb; 16 (68): 57–62.
20. Holand S., Girard A., Laude D., Meyer-Bisch C., Elghozi J.L.: Effects of an auditory startle stimulus on blood pressure and heart rate in humans. J Hypertens. 1999; 17 (12 Pt 2): 1893–1897.
21. Ernst G.: Hidden Signals-The History and Methods of Heart Rate Variability. Front Public Health. 2017 Oct 16; 5: 265.
22. Carrillo A.E., Flouris A.D., Herry C.L., et al.: Heart rate variability during high heat stress: a comparison between young and older adults with and without Type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2016 Oct 1; 311 (4): R669–R675.
23. Wang X., Liu B., Xie L., Yu X., Li M., Zhang J.: Cerebral and neural regulation of cardiovascular activity during mental stress. Biomed Eng Online. 2016 Dec 28; 15 (Suppl 2): 160.
24. Castaldo R., Xu W., Melillo P., Pecchia L., Santamaria L., James C.: Detection of mental stress due to oral academic examination via ultra-short-term HRV analysis. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016: 3805–3808.
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Authors and Affiliations

Michał Jurczyk
1
Andrzej Boryczko
1
Agata Furgała
1
Adrian Poniatowski
1
Andrzej Surdacki
2
Krzysztof Gil
1

  1. Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
  2. Second Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland

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