The environment in general and the marine environment in particular forms an ecosystem. Such ecosystem is characterized by high interconnectivity and interdepen-dence of species inhabiting it. Often enough, marine ecosystems far exceed the limits of the State’s sovereignty. Thus, their effective protection and preservation shall be carried out on a cooperative basis, engaging all States sharing common environment. The first international treaty to tackle the issue of marine environmental protection on a systemic basis is the United Nations Convention on the Law of the Sea (UNCLOS). It is also a treaty which directly established an obligation to cooperate in ensuring this protection. However, homogenous international regulation is not capable of addressing regional varying circumstances of marine environment. As the example of the South China Sea shows, lack of cooperation between coastal States can result in an irreversible damage to the environment. On the other hand, a remarkable model of effective realization of the obligation to cooperate has been established in the region of the Baltic Sea. What we can learn from these experiences is that fulfillment of the obligation to cooperate on a re-gional basis is a prerequisite for effective protection and preservation of the marine environment.