In this article we present an industrial application of our mathematical model that integrates
planning and scheduling. Our main objective is to concretize our model and compare the
reel results with the theoretical ones. Our application is realized on a conditioning line of
pharmaceutical products at the ECAM EPMI production laboratory. For this reason and to
save time, we used Witness simulation tool. It gives an overall idea of how the line works,
the Makespan of each simulation and it highlights areas for improvement. We looked for
the best resulting sequence which corresponds to the minest Makespan and total production
cost. Then this sequence is applied on the conditioning line of pharmaceutical products for
simulation. On the other hand, we program our mathematical model with the parameters of
the conditioning line under python in version 3.6 and we adopt a simulation/optimization
coupling approach to verify our model.