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Abstract

Florfenicol is a broad-spectrum bacteriostatic antibiotic commonly used for the treatment of systemic infections in farm animals. The aim of this study was to determine the effect of florfenicol on the percentage of T lymphocytes (CD3+, CD4+, CD8+, TCRgd+ cells) and B lymphocytes (Bu-1+ cells) and on total serum anti - sheep red blood cell (SRBC) haemagglutinin titer in the peripheral blood of SRBC–immunized broiler chickens. The study included three groups of broiler chickens differentiated by weight (0.5, 1.2, 2.4 kg). Florfenicol was administered orally at a dose of 30 mg/kg. The drug was administered eight times at 24 h intervals. The chickens were immunized with SRBC 24 h after administration of the third dose of florfenicol. Florfenicol increased the percentage of CD3+ blood lymphocytes with a corresponding decrease in the percentage of B lymphocytes in birds weighing 0.5 and 2.4 kg. Florfenicol reduced the production of total anti SRBC-haemagglutinins on day 5 after antigen injection in all three body weight groups of the broiler chickens. In conclusion, florfenicol exerted a modulating effect on the immune response of the birds and this should be taken into consideration when using this antibiotic for certain indications.

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Authors and Affiliations

M. Lis
M. Szczypka
A. Suszko-Pawłowska
M. Świtała
P. Pawłowski
B. Obmińska-Mrukowicz
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Abstract

This paper presents equilibrium mechanics and a finite element model for analysing a scissor structure that contains pivots with zero bending stiffness representing structural instability. The pivot at the centre of each structural unit, which is a feature of scissor structures, can be used to transfer the displacement between the units. It cannot, however, transfer the rotation between these units, and the angular stiffness must be considered independently for each unit. To construct a general model of the scissor structure, a scissor unit was developed using the left and right boundary connections of adjacent units to simulate a periodically symmetric structure. The proposed method allows us to obtain an accurate distribution of the internal forces and deflections without the use of special elements to account for central pivots.

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Authors and Affiliations

I. Ario
T. Yamashita
Y. Chikahiro
M. Nakazawa
K. Fedor
C. Graczykowski
P. Pawłowski

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