In this paper analyses of mode distribution, confinement and experimental losses of the photonic crystal fibers with different core sizes infiltrated with liquid crystal are presented. Four types of fibers are compared: with single-, seven-, nineteen- and thirty seven solid rods forming the core in the same hexagonal lattice of seven “rings” of unit cells (rods or capillaries). The experimental results confirming the influence of the core diameter on light propagation are also included. The diameter of cores determines not only the number of modes in the photonic liquid crystal fiber but also is correlated with experimentally observed attenuation. For fibers with larger cores confinement losses are expected to be higher, but the measured attenuation is smaller because the impact of liquid crystal material losses and scattering is smaller.