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Number of results: 17
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Abstract

Centroblastic lymphoma (CBL) is the most common type of lymphoma in dogs and it usually responds well to chemotherapy. The aim of the study was to provide useful prognostic factors for dogs with CBL. Data regarding sex, breed, age, signalment, treatment and clinical course of the disease from 52 dogs diagnosed with centroblastic lymphoma (CBL) with cytology and immunocytochemistry were provisionally collected and related to the treatment outcome and survival. More than 80% of dogs were treated with chemotherapy and achieved complete remission in 80% of cases. Among the prognostic factors positively related to the overall survival time of dogs with CBL were: the application of chemotherapy, achieving a complete remission, application of at least one additional chemotherapeutic agent to the basic protocol, especially the administration of mitoxantrone and asparaginase. Moreover, mitotic count 14 or higher measured in cytological slides in the area of 2,37 mm2 have been linked to shorter overall survival in dogs with CBL.
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Authors and Affiliations

K. Kliczkowska-Klarowicz
1
D. Jagielski
2
M. Czopowicz
3
R. Sapierzyński
1

  1. Division of Pathology, Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-776 Warsaw
  2. Białobrzeska Veterinary Surgery in Warsaw, Poland
  3. Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02-776 Warsaw, Poland
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Abstract

In the literature the occurrence of thymomas in goats varies from 0.7 to 25%, depending on the study. Therefore the current investigation was carried out to determine the prevalence of thymoma in goats in Poland. Between 2007 and 2018 at the Warsaw Veterinary Faculty 399 goat autopsies and ultrasound examinations of the chest in other 145 goats were performed. Mediastinal tumors were diagnosed during post mortem examination in 2 goats. Additionally, ultrasound examination of the chest revealed a large mass close to the heart in the thoracic cavity in 1 case. This goat was euthanized and an autopsy confirmed a mediastinal tumor. Histopathological examination, with immunohistochemical tests to anti cytokeratin, p63 and p40 confirmed thymomas in all three cases. In our study thymomas were found in 0.5% (95% CI: 0.1% to 1.8%) of examined goats and they represented the most common malignancy in this species.

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Authors and Affiliations

O. Szaluś-Jordanow
M. Czopowicz
L. Witkowski
M. Mickiewicz
A. Moroz
J. Kaba
R. Sapierzyński
J. Bonecka
I. Jońska
M. Garncarz
M. Kwiatkowska
D. Chutorański
M. Szołkowska
T. Frymus

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