The roadway surrounding rock is often subjected to severe damage under dynamic loading at greater mining depths. To study the dynamic response of prestressed anchors, the damage characteristics of anchor solids with different prestresses and number of impacts under dynamic and static loads were investigated by improving the Hopkinson bar equipment. The effect of prestress on stress wave transmission was obtained, and the laws and reasons for axial force loss under static and dynamic loads were analyzed. The damage characteristics of anchor solids were determined experimentally. The results show that with an increase in prestress from 15 to 30 MPa, the peak value of the stress wave gradually increases and the decay rate gradually decreases. Shear damage occurred at the impact end of the specimen, combined tension and shear damage occurred at the free end, and fracture occurred in the middle. With an increase in the number of impacts, the damage to the anchor solid specimens gradually increased, and the prestressing force gradually decreased. After impact, the axial force of the various prestressed anchor solid specimens gradually increased; however, the anchor bar with a 17 MPa prestressing force had the slowest rate of axial force loss during impact, withstanding a greater number of impacts. In on-site applications, after three explosions, the displacement on both sides of the tunnel supported by 17 MPa prestressed anchor rods could be controlled within 0.3 m, with an average displacement of 206, 240, and 283 mm, respectively, increasing by 16.5% and 17.9%. This study, based on theoretical analysis and laboratory research combined with field application provides guidance for the anchor support of a dynamic loading tunnel.