In this paper, an autonomous wearable sensor node is developed for long-term continuous healthcare monitoring. This node is used to monitor the body temperature and heart rate of a human through a mobile application. Thus, it includes a temperature sensor, a heart pulse sensor, a low-power microcontroller, and a Bluetooth low energy (BLE) module. The power supply of the node is a lithium-ion rechargeable battery, but this battery has a limited lifetime. Therefore, a photovoltaic (PV) energy harvesting system is proposed to prolong the battery lifetime of the sensor node. The PV energy harvesting system consists of a flexible photovoltaic panel, and a charging controller. This PV energy harvesting system is practically tested outdoor under lighting intensity of 1000 W/m2. Experimentally, the overall power consumption of the node is 4.97 mW and its lifetime about 246 hours in active-sleep mode. Finally, the experimental results demonstrate long-term and sustainable operation for the wearable sensor node.