Search results

Filters

  • Journals
  • Authors
  • Keywords
  • Date
  • Type

Search results

Number of results: 16
items per page: 25 50 75
Sort by:
Download PDF Download RIS Download Bibtex

Abstract

Previous studies have compared the effectiveness of dinoprost and cloprostenol in cows yielding conflicting results. The aim of our study was to evaluate the efficacy of single treatment with cloprostenol or dinoprost on estrus and reproductive performance in cows with unobserved estrus after service. The study was conducted over four years in two dairy herds of Polish Holstein Frisian cows under a herd health program with an average milk yield per cow over 9000 L. Cows (n=523) diagnosed ultrasonographically as non-pregnant and with a corpus luteum were randomly assigned to be treated with either cloprostenol (n=261) or dinoprost (n=262). The estrus detection rates after administration of cloprostenol or dinoprost were 59.4%, and 57.6%, respectively. The difference between both groups was not statistically significant (p>0.05). Distribution of observed estrus did not differ between cloprostenol and dinoprost. There were no differences (p>0.05) between cloprostenol and dinoprost in conception rate (65.2% vs. 66.2%, respectively) and pregnancy rate (57.5% vs. 54.9%, respectively). Mean days open were similar in cows of both treatments (177.5 ± 74.6 days vs. 175.8 ± 62.6 days, respectively; p>0.05). In conclusion, data from this study showed no significant differences in estrus detection rates and fertility between cows with unobserved estrus after service treated with cloprostenol or dinoprost. Both products are equally useful for the treatment of non-pregnant dairy cows with anestrus after service within a reproductive herd health program.
Go to article

Authors and Affiliations

A. Baryczka
W. Barański
A. Nowicki
S. Zduńczyk
T. Janowski
Download PDF Download RIS Download Bibtex

Abstract

There is no information available about the incidence of anestrus and its clinical forms after service in dairy cows in Poland. Thus, the aim of this study was to investigate the incidence of clinical forms of anoestrus after unsuccessful artificial insemination in dairy cows based on ultrasound examination. The study was carried out on 1543 Polish Holstein-Friesian cows in 8 dairy herds in north-east Poland over a three-year period. Cows were examined for pregnancy on day 35 after AI using a Honda 1500 portable ultrasound scanner equipped with a 5 MHz linear-array transducer. Cows diagnosed as pregnant were re-examined on day 45. Of the 1543 inseminated cows, 408 (26.4%) showed no estrus signs and were diagnosed not-pregnant by ultrasonography, 328 (21.3%) returned to estrus within 35 days, and 807 (52.3%) were pregnant via artificial insemination. The incidence of anestrus after service in non-pregnant cows varied among herds from 10.3% to 32.9% of cows (p<0.05). Based on ultrasound examination silent heat was diagnosed in 324 (79.4%), corpus luteum pseudograviditatis in 36 (8.8%), ovarian cysts in 26 (6.4%), and ovarian afunction in 22 (5.4%) of 408 anestrous, non-pregnant cows. The results of this study showed that the incidence of anestrus after service in dairy herds in North-East Poland was high. The most prevalent clinical form of post-service anestrus was silent heat.
Go to article

Authors and Affiliations

W. Barański
A. Nowicki
S. Zduńczyk
T. Janowski
Download PDF Download RIS Download Bibtex

Abstract

The study was carried out in 5 dairy herds of Polish Holstein-Friesian cows. The average milk yield was about 9000 kg per year. For each herd, the following fertility parameters were calculated at the start of the program and 4 years later: first- service conception rate, services per conception, length of inter-calving period and culling rate due to infertility. The incidence of silent heat, ovarian cysts, ovarian afunction, retained placenta and clinical endometritis was also recorded. Four years after implementation of the program, the average first-service conception rate increased from 43.2% to 51.2%. In three herds the differences were statistically significant (p<0.05). There was also a decrease in the number of services per pregnancy and in the culling rate due to infertility. Fertility performance was maintained in two herds. The average incidence of silent heat decreased from 38.1% to 29.7% and the difference was statistically significant (p<0.05) in three herds. There was no significant reduction in incidence of other reproductive disorders during the 4 years except for clinical endometritis in one herd. The average milk yield increased from 9300 kg to 9530 kg milk per cow per year. In conclusion, the results indicate that the implementation of the integrated veterinary herd health program improved or maintained fertility performance despite an increase in milk yield.
Go to article

Bibliography


Barański W, Janowski T, Raś M, Zduńczyk S, Opsomer G, Dewulf J, de Kruif A (2008) Incidence of reproduction disorders and fertility parameters in dairy herds under the herd health program. Med Weter 64: 807-811.
Bogucki M, Sawa A, Neja W (2007) Differences in fertility parameters of dairy cows due to increasing lactation yield. Acta Sci Pol Zootech 6: 3-10.
Borkowska D, Piatek D, Januś E, Mucha J (2012) Fertility indices of cows in a high-yielding herd. Rocz Nauk PTZ 8: 21-29.
Butler WR (2003) Energy balance relationships with follicular development, ovulation and fertility in postpartum dairy cows. Livest Prod Sci 83: 211-218.
de Kruif A, Opsomer G (2004) Integrated dairy herd health management as the basis for prevention. Vlaams Diergeneeskd Tijdschr 73: 44-52.
de Kruif A, Leroy J, Opsomer G (2008) Reproductive performance in high producing dairy cows: practical implications. Tierarztl Prax 36 (Suppl 1): 29-33.
Derks M, van Werven T, Hogeveen H, Kremer WD (2013) Veterinary herd health management programs on dairy farms in the Netherlands: use, execution, and relations to farmer characteristics. J Dairy Sci 96: 1623-1637.
Dobson H, Smith R, Royal M, Knight CH, Sheldon I (2007) The high-producing dairy cow and its reproductive performance. Reprod Domest Anim 42 (Suppl 2): 17-23.
Dobson H, Walker SL, Morris MJ, Routly JE, Smith RF (2008) Why is it getting more difficult to successfully artificially inseminate dairy cows? Animal 2: 1104-1111.
Dymnicki E, Krzyżewski J, Oprządek J, Reklewski Z, Oprządek A (2003) Relationship between the length of calving intervals and milk trace in black-and-white cows. Med Weter 9: 792-796.
Januś E, Borkowska D (2012) Correlations between milk yield in primiparous PHF cows and selected lifetime performance and fertility indi-cators as well as reasons for culling, Acta Sci Pol Zootech 11: 23-32.
Lopez H, Satter LD, Wiltbank MC (2004) Relationship between level of milk production and estrous behavior of lactating dairy cows. Anim Reprod Sci 81: 209-223.
Lucy MC (2007) Fertility in high-producing dairy cows: reasons for decline and corrective strategies for sustainable improvement. Soc Reprod Fertil Suppl. 64: 237-254.
Mee JF (2007) The role of the veterinarian in bovine fertility management on modern dairy farms. Theriogenology 68 (Suppl 1): 257-265.
Mee JF (2010) Veterinary dairy herd fertility service provision in seasonal and non-seasonal dairy industries – a comparison. Ir Vet J 63: 230-235.
Morek-Kopeć M, Żarnecki A (2009) Culling reasons in the population of Polish Holstein-Friesian Black and White cows. Rocz Nauk PTZ 5: 9-17.
Noordhuizen JP, Wentink GH (2001) Developments in veterinary herd health programmes on dairy farms: a review. Vet Q 23: 162-169.
Norman HD, Wright JR, Hubbard SM, Miller RH, Hutchison JL (2009) Reproductive status of Holstein and Jersey cows in the United States. J Dairy Sci 92: 3517-3528.
Polska Federacja Hodowców Bydła i Producentów Mleka (PFHBiPM) (2020) Evaluation and breeding of dairy cattle. Dane za rok 2019. pfhb.pl PFHBiPM Wyniki poglad 2020 WEB.
Roche JF (2006) The effect of nutritional management of the dairy cow on reproductive efficiency. Anim Reprod Sci 96: 282-296.
Royal M, Mann GE, Flint AP (2000) Strategies for reversing the trend towards subfertility in dairy cattle. Vet J 160: 53-60.
Sangsritavong S, Combs DK, Sartori R, Armentano LE, Wiltbank MC (2002) High feed intake increases liver blood flow and metabolism of progesterone and estra- diol-17beta in dairy cattle. J Dairy Sci 85: 2831-2842.
Walsh SW, Williams EJ, Evans AC (2011) A review of the causes of poor fertility in high milk producing dairy cows. Anim Reprod Sci 123: 127-138.
Wiltbank M, Lopez H, Sartori R, Sangsritavong S, Gümen A (2006) Changes in reproductive physiology of lactating dairy cows due to ele-vated steroid metabolism. Therio- genology 65: 17-29.
Zduńczyk S, Janowski T, Raś M (2005) Current views on the phenomenon of silent heat in cows. Med Weter 61: 726-729.
Go to article

Authors and Affiliations

W. Barański
1
A. Nowicki
1
S. Zduńczyk
1

  1. Department of Animal Reproduction with Clinic, University of Warmia and Mazury, ul. Oczapowskiego 14, 10-719 Olsztyn, Poland
Download PDF Download RIS Download Bibtex

Abstract

The aim of this study was to evaluate the efficacy of the Ovsynch protocol in the treatment of post-service subestrus in individual dairy cows compared to a single administration of PGF2α. The study was performed on 517 Polish Friesian Holstein cows with post-service anestrus over four years in 3 dairy herds under a herd health program. Cows (n=240) diagnosed ultrasonographically as non-pregnant and with a mature corpus were treated with a single PGF2α administration and inseminated at detected estrus. Cows without corpus (n=277) were treated with the Ovsynch protocol. The estrus detection rate after PGF2α administration, percentages of cows pregnant after the treatment and at day 260, intervals from parturition to treatment and from treatment to conception and pregnancy loss rates were calculated. The overall percentage of cows pregnant after treatment did not differ between animals treated with the Ovsynch protocol and with PGF2α (38.9% vs. 42.5%; p>0.05). In herd A the percentage of cows pregnant after treatment was significantly lower (p<0.05) for the Ovsynch group than for the PGF2α group (30.2% vs. 61.2%). In contrast, in herd C the percentage of cows pregnant after treatment was significantly higher (p<0.05) in the Ovsych group than in the PGF2α group (39.6% vs. 28.8%). The overall estrus detection rate after administration of PGF2α was 59.6%. However, it was significantly lower (p<0.05) in herd C (44.7%) than in herds A (79.6%) and B (76.3%). The overall pregnancy loss rate ranged from 5.1% to 13.3% and did not differ significantly between herds and treatment groups (p>0.05). In conclusion, Ovsynch protocol can be a useful alternative for treatment of post-service suboestrus in individual cows in dairy herds with insufficient oestrus detection.
Go to article

Bibliography


Barański W, Nowicki A, Zduńczyk S, Janowski T (2018) Incidence of clinical form of anestrus after unsuccessful service in cows in eight dairy herds in north-east of Poland. Pol J Vet Sci 21: 377-381.
Barański W, Zduńczyk S, Janowski T (2012) Late embryonic and foetal losses in eight dairy herds in north-east Poland. Pol J Vet Sci 15: 735-739.
Bartlett PC, Kirk J, Coe P, Marteniuk J, Mather EC (1987) Descriptive epidemiology of anestrus in Michigan Holstein-Friesian cattle. Theriogenology 27: 459-476.
Baryczka A, Barański W, Nowicki A, Zduńczyk S, Janowski T (2018) Effect of single treatment with cloprostenol or dinoprost on estrus and reproductive performance in anestrous dairy cows after service. Pol J Vet Sci 21: 383-387.
Dobson H, Walker SL, Morris MJ, Routly JE, Smith RF (2008) Why is it getting more difficult to successfully artificially inseminate dairy cows? Animal 2: 1104-1111.
Forar AL, Gay JM, Hancock DD, Gay CC (1996) Fetal loss frequency in ten Holstein dairy herds. Theriogenology 45: 1505-1513.
Lopez H, Satter LD, Wiltbank MC (2004) Relationship between level of milk production and estrous behavior of lactating dairy cows. Anim Reprod Sci 81: 209-223.
Lucy MC (2001) Reproductive loss in high-producing dairy cattle: where will it end? J Dairy Sci 84: 1277-1293.
Martinez J, Thibier M (1984) Reproductive disorders in dairy cattle: I. Respective influence of herds, seasons, milk yield and parity. Theri-ogenology 21: 569-581.
Mateus L, da Costa LL, Cardos JJ, Silva JR (2002) Treatment of unobserved oestrus in a dairy cattle herd with low oestrous detection rate up to 60 days post-partum. Reprod Domest Anim 37: 57-60.
McDougall S (2010) Effects of treatment of anestrous dairy cows with gonadotropin-releasing hormone, prostaglandin, and progesterone. J Dairy Sci 93: 1944-1959.
Mwaanga ES, Janowski T, Zduńczyk S (1999) Incidence of silent heat in cows and the effectiveness of its diagnosis and treatment with PGF2 alpha analogue, cloprostenol. Pol J Vet Sci 2: 109-112.
Nation DP, Morton J, Cavalieri J, MacMillan KL (2001) Factors associated with the incidence of ‘Phantom cows’ in Australian dairy herds. Proc N Z Soc Anim Prod 61: 180-183.
Nowicki A, Barański W, Baryczka A, Janowski T (2017) OvSynch Protocol and its Modifications in the Reproduction Management of Dairy Cattle Herds - an Update. J Vet Res 61: 329-336.
Paisley LG, Mickelsen WD, Frost OL (1978) A survey of the incidence of prenatal mortality in cattle following pregnancy diagnosis by rectal palpation. Theriogenology 9: 481-491.
Pilawski W, Siemieniuch MJ, Skarżyński DJ (2008) Influence of estrus synchronization and superovulation on corpus luteum functioning in cattle. Does hormonal manipulation always provide desirable effects? Med Weter 64: 525-527.
Plunkett SS, Stevenson JS, Call EP (1984) Prostaglandin F2 alpha for lactating dairy cows with a palpable corpus luteum but unobserved estrus. J Dairy Sci 67: 380-387.
Pursley JR, Mee MO, Wiltbank MC (1995) Synchronization of ovulation in dairy cows using PGF2alpha and GnRH. Theriogenology 44: 915-923.
Rabiee AR, Lean IJ, Stevenson MA (2005) Efficacy of Ovsynch program on reproductive performance in dairy cattle: a meta-analysis. J Dairy Sci 88: 2754-2770.
Répási A, Beckers JF, Sulon J, Karen A, Reiczigel J, Szenci O (2005) Effect of the type and number of prostaglandin treatments on corpus luteum, the largest follicle and progesterone concentration in dairy cows. Reprod Domest Anim 40: 436-442.
Rhodes FM, McDougall S, Burke CR, Verkerk GA, Macmillan KL (2003) Invited review: Treatment of cows with an extended postpartum anestrous interval. J Dairy Sci 86: 1876-1894.
Seguin B, Momont H, Baumann L (1985) C1oprostenol and dinoprost tromethamine in experimental and field trials treating unobserved estrus in dairy cows. Bovine Pract 20: 85-90.
Skarżynski DJ, Siemieniuch MJ, Pilawski W, Wocławek Potocka I, Bah MM, Majewska M, Jaroszewski JJ (2008) In vitro assessment of progesterone and prostaglandin E2 production by the corpus luteum in cattle following pharmacological synchronization of estrus. J Reprod Dev 55: 170-176.
Stevenson JS, Pursley JR (1994) Use of milk progesterone and prostaglandin F2 alpha in a scheduled artificial insemination program. J Dairy Sci 77: 1755-1760.
Szenci O, Beckers JF, Humblot P, Sulon J, Sasser G, Taverne MA, Varga J, Baltusen R, Schekk G (1998) Comparison of ultrasonography, bovine pregnancy-specific protein B, and bovine pregnancy-associated glycoprotein 1 test for pregnancy detection in dairy cows. Theriogeno- logy 50: 77-88.
Go to article

Authors and Affiliations

W. Barański
1
A. Nowicki
1
S. Zduńczyk
1

  1. Department of Animal Reproduction with Clinic, University of Warmia and Mazury, ul. Oczapowskiego 14, 10-719 Olsztyn, Poland
Download PDF Download RIS Download Bibtex

Abstract

The aim of this study was to evaluate the fertility response of dairy cows with anovulation type I on repeated low doses of GnRH agonist buserelin. The study was conducted on 83 anovulatory and 60 cyclic Polish Holstein Friesian cows. Anovulation type I was defined as small ovaries with follicles of ≤ 5 mm in diameter and without corpus luteum on two examinations in a 7-10 day interval between 50–60 days after parturition. Cows from the experimental group (n=58) received 0.4 μg of buserelin i.m. once a day for 5 consecutive days. Cows from the negative control group (n = 25) received saline. Sixty cyclic cows receiving no treatment served as positive controls. Intervals from calving to estrus and from calving to conception, pregnancy rate 30-35 days and 260 days after AI, and pregnancy loss were calculated. The anovulatory cows had a substantially prolonged calving to conception interval, decreased pregnancy rate and increased pregnancy loss and culling rate compared to cyclic herd mates. The average calving to conception interval was significantly (p<0.05) shorter in treated cows compared to non-treated anovulatory cows (153.7 days vs 209.3 days). In conclusion, repeated low doses of GnRH analogue buserelin led to a significant shortening of calving to conception interval. More clinical trials are needed to determine the practical usefulness of this method for the treatment of anovulation type I in dairy cows.
Go to article

Authors and Affiliations

W. Barański
1
A. Nowicki
1
S. Zduńczyk
1
Z. Polak
1

  1. Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland
Download PDF Download RIS Download Bibtex

Abstract

The aim of the study was to evaluate the effect of repeated low doses of GnRH agonist buserelin once a day for 5 days on follicle development and ovulation in anovulatory dairy cows with follicles growth only to emergence. The study was conducted on 71 anovulatory Polish Holstein Friesian cows. Anovulation with growth of follicles to emergence was defined as small ovaries with follicles of ≤ 5 mm in diameter and without corpus luteum on two examinations in a 7-10 day interval between 50-60 days after parturition. Cows were allocated to one of two group. Cows from group 1 (n = 58) received 0.4 μg of buserelin (Receptal, MSD, Poland) i.m. once a day for 5 days. Control cows from group 2 (n = 13) received saline. Ovarian structures were monitored weekly after the end of treatment by ultrasound for 4 weeks. The diameter of ovarian follicles on the ovaries was measured and recorded. Occurrence of ovulation was determined by the presence of corpus luteum. Overall, ovulation occurred in 46.6% (27/58) of cows treated with repeated doses of GnRH, while no corpus luteum was observed in the control group during the study period. There were significantly (p<0.05) more follicles 6-9 mm in diameter and 10-20 mm in diameter in cows treated with GnRH than in control cows. In conclusion, repeated low doses of GnRH analogue buserelin once a day for 5 days stimulate the development of ovarian follicles in anovulatory dairy cows with small ovarian follicles and led to ovulation in 46.6% of cows during 4 weeks after the end of the treatment.
Go to article

Authors and Affiliations

W. Barański
1
A. Nowicki
1
S. Zduńczyk
1
D. Tobolski
1

  1. Department of Animal Reproduction with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland
Download PDF Download RIS Download Bibtex

Abstract

The aim of this study was to evaluate the antioxidative/oxidative status of spermatozoa and prostatic fluid in dogs with benign prostatic hyperplasia (BPH) by the determination of total antioxidant capacity and protein peroxidation markers. Study was conducted on 40 intact dogs of various breeds. The dogs were assigned to two groups: BPH group (n=20) and non-affected group (n=20). The second and third fractions of the ejaculate were collected separately by digital manipulation. Total antioxidant capacity (TAC) and the concentrations of SH-groups in sperm and prostatic fluid were determined spectrophotometrically, the concentrations of bityrosine and formylkynurenine were determined using spectrofluorimetric methods. The mean values of TAC in spermatozoa and prostatic fluid were significantly lower (p<0.05), whereas the mean contents of biotyrosine and formylkinurenine were significantly higher (p<0.05) in BPH dogs compared to control dogs. There was no statistically significant difference in the content of SH group between dogs with BPH and control dogs (p>0.05). In conclusion, the results indicate that BPH in dogs is associated with reduced total antioxidant capacity and increased protein oxidation in the prostatic fluid and spermatozoa, and suggest the importance of oxidative stress in the pathogenesis of this condition. The potential role of antioxidants in the prevention and therapy of canine BPH requires further studies.
Go to article

Bibliography

1. Al Smadi MA, Hammadeh ME, Batiha O, Al Sharu E, Altalib MM, Jahmani MY, Mahdy A, Amor H (2021) Elevated seminal protein carbonyl concentration is correlated with asthenozoospermia and affects adversely the laboratory intracytoplasmic sperm injection (ICSI) outcomes. Andrologia 53: e14232.
2. Angrimani DS, Brito MM, Rui BR, Nichi M, Vannucchi CI (2020) Reproductive and endocrinological effects of Benign Prostatic Hy-perplasia and finasteride therapy in dogs. Sci Rep 10: 14834.
3. Aquino-Cortez A, Pinheiro BQ, Lima DB, Silva HV, Mota-Filho AC, Martins JA, Rodriguez-Villamil P, Moura AA, Silva LD (2017) Proteomic characterization of canine seminal plasma. Theriogenology 95: 178-186.
4. Aydin A, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, Ozgok Y, Dimovski A (2006) Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia. Clin Biochem 39: 176-179.
5. Barsanti JA, Finco DR (1986) Canine prostatic diseases. Vet Clin North Am Small Anim Pract 16: 587-599.
6. Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of „antioxidant power”: The FRAP assay. Anal Biochem 239: 70-76.
7. Bergsma AT, Li HT, Eliveld J, Bulthuis ML, Hoek A, van Goor H, Bourgonje AR, Cantineau AE (2022) Local and systemic oxidative stress biomarkers for male infertility: The ORION study. Antioxidants (Basel) 11: 1045.
8. Berry SJ, Strandberg JD, Saunders WJ, Coffey DS (1986) Development of canine benign prostatic hyperplasia with age. Prostate 9: 363-373.
9. Castleton PE, Deluao JC, Sharkey DJ, McPherson NO (2022) Measuring reactive oxygen species in semen for male preconception care: A scientist perspective. Antioxidants (Basel) 11: 264.
10. Cunto M, Ballotta G, Zambelli D (2022) Benign prostatic hyperplasia in the dog. Anim Reprod Sci 247: 107096.
11. Da Rocha AA, da Cunha ICN, Ederli BB, Albernaz AP, Quirino CR (2009) Effect of daily food supplementation with essential fatty ac-ids on canine semen quality. Reprod Dom Anim 44, (Suppl 2): 313-315.
12. Dearakhshandeh N, Mogheiseh A, Nazifi S, Ahrari Khafi MS, Abbaszadeh Hasiri M, Golchin-Rad K (2019) Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH-induced dogs with an anti-proliferative agent called tadalafil. J Vet Pharmacol Ther 42: 665-672.
13. De Souza FF, Barreto CS, Lopes MD (2007) Characteristics of seminal plasma proteins and their correlation with canine semen analysis. Theriogenology 68: 100-106.
14. Domosławska A, Zdunczyk S (2020) Clinical and spermatological findings in male dogs with acquired infertility: A retrospective analy-sis. Andrologia 52: e13802.
15. Domoslawska A, Zdunczyk S, Franczyk M, Kankofer M, Janowski T (2018) Selenium and vitamin E supplementation enhances the an-tioxidant status of spermatozoa and improves semen quality in male dogs with lowered fertility. Andrologia 50: e13023
16. Domosławska A, Zdunczyk S, Franczyk M, Kankofer M, Janowski T (2019) Total antioxidant capacity and protein peroxidation inten-sity in seminal plasma of infertile and fertile dogs. Reprod Domest Anim 54: 252-257.
17. Domosławska A, Zduńczyk S, Kankofer M, Bielecka A (2022) Oxidative stress biomarkers in dogs with benign prostatic hyperplasia. Ir Vet J 75: 21.
18. Ferré-Dolcet L, Frigotto L, Contiero B, Bedin S, Romagnoli S (2022) Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate. Reprod Domest Anim 57: 72-79.
19. Fontbonne A (2011) Infertility in male dogs: recent advances. Rev Bras Reprod Anim 35: 266-273.
20. Gandaglia G, Briganti A, Gontero P, Mondaini N, Novara G, Salonia A, Sciarra A, Montorsi F (2013) The role of chronic prostatic in-flammation in the pathogenesis and progression of benign prostatic hyperplasia (BPH). BJU Int 112: 432-441.
21. Ghiselli A, Serafini M, Natella F, Scaccini C (2000) Total antioxidant capacity as a tool to assess redox status: critical view and experi-mental data. Free Radic Biol Med 29: 1106-1114.
22. Gobello C, Corrada Y (2002) Noninfectious prostatic diseases in dogs. Compend Contin Educ Pract Vet 24: 99-107.
23. Halliwell B, Whiteman M (2004) Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? Br J Pharmacol 142: 231-255.
24. Kankofer M (2001) Protein peroxidation processes in bovine retained and not-retained placenta. J Vet Med A Physiol Pathol Clin Med 48: 207-2212.
25. Kawakami E, Kobayashi M, Hori T, Kaneda T (2015) Therapeutic effects of vitamin E in 4 dogs with poor semen quality and low su-peroxide dismutase activity in seminal plasma. J Vet Med Sci 77: 1711-1714.
26. Lévy X, Niżański W, von Heimendahl A, Mimouni P (2014) Diagnosis of common prostatic conditions in dogs: an update. Reprod Domest Anim 49 (Suppl 2): 50-57.
27. Linde-Forsberg C (1991) Achieving canine pregnancy by using frozen or chilled extended semen. Vet Clin North Am Small Anim Pract 21: 467-485.
28. Meikle AW, Collier ES, Stringham JD, Fang SM, Taylor GN (1981) Elevated intranuclear dihydrotestosterone in prostatic hyperplasia of aging dogs. J Steroid Biochem 14: 331-335.
29. Memon MA (2007) Common causes of male dog infertility. Theriogenology 68: 322-328.
30. Minciullo PL, Inferrera A, Navarra M, Calapai G, Magno C, Gangemi S (2015) Oxidative stress in benign prostatic hyperplasia: a sys-tematic review. Urol Int 94: 249-254.
31. Mitsunari K, Miyata Y, Matsuo T, Mukae Y, Otsubo A, Harada J, Kondo T, Matsuda T, Ohba K, Sakai H (2021) Pharmacological Ef-fects and Potential Clinical Usefulness of Polyphenols in Benign Prostatic Hyperplasia. Molecules 26: 450.
32. Morielli T, O’Flaherty C (2015) Oxidative stress impairs function and increases redox protein modifications in human spermatozoa. Re-production 149: 113-23.
33. Nowicka-Bauer K, Lepczynski A, Ozgo M, Kamieniczna M, Fraczek M, Stanski L, Olszewska M, Malcher A, Skrzypczak W, Kurpisz MK (2018) Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia. J Physiol Phar-macol 69.
34. Pace G, Di Massimo C, De Amicis D, Corbacelli C, Di Renzo L, Vicentini C, Miano L, Tozzi Ciancarelli MG (2010) Oxidative stress in benign prostatic hyperplasia and prostate cancer. Urol Int 85: 328-333.
35. Rice- Evans CA, Diplock AT, Symons MCR (1991) Techniques in Free Radical Research, 1st ed., Elsevier, Amsterdam.
36. Roumeguère T, Sfeir J, El Rassy E, Albisinni S, Van Antwerpen P, Boudjeltia KZ, Farès N, Kattan J, Aoun F (2017) Oxidative stress and prostatic diseases. Mol Clin Oncol 7: 723-728.
37. Schäfer-Somi S (2023) Diseases of the Canine Prostate Gland. IntechOpen. Doi: 10.5772/intechopen.105835.
38. Smith J (2008) Canine prostatic disease: a review of anatomy, pathology, diagnosis, and treatment. Theriogenology 70: 375-383.
39. Srivastava DS, Mittal RD (2005) Free radical injury and antioxidant status in patients with benign prostate hyperplasia and prostate can-cer. Indian J Clin Biochem 20: 162-165.
40. Stadtman ER, Levine RL (2000) Protein oxidation. Ann N Y Acad Sci 899: 191-208.
41. Stewart KL, Lephart ED (2023) Overview of BPH: Symptom Relief with Dietary Polyphenols, Vitamins and Phytochemicals by Nutraceutical Supplements with Implications to the Prostate Microbiome. Int J Mol Sci 24: 5486.
42. Strzeżek R, Koziorowska-Gilun M, Kowalówka M, Strzeżek J (2009) Characteristics of antioxidant system in dog semen. Pol J Vet Sci 12: 55-60.
43. Tong Y, Zhou RY (2020) Review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia. Mediators Inflamm 2020: 7958316.
44. Tunn S, Hochstrate H, Habenicht UF, Krieg M (1988) 5 alpha-reductase activity in epithelium and stroma of prostates from intact and castrated dogs treated with androstenedione, the aromatase inhibitor 1-methyl-1,4androstadiene-3,17-dione, and cyproterone acetate. Prostate 12: 243-253.
45. Vital P, Castro P, Ittmann M (2016) Oxidative stress promotes benign prostatic hyperplasia. Prostate 76: 58-67.
46. Worobiej E, Klepacka M (2003) Degradation changes induced by hydroxyl radicals in bean (Phaseolus vulgaris) and pea (Pisum sa-tivum) proteins. Pol J Food Nutr Sci 53: 13-17.
Go to article

Authors and Affiliations

A. Domosławska
1
S. Zduńczyk
1
A. Bielecka
2
M. Kankofer
2

  1. Department of Animal Reproduction with Clinic, University of Warmia and Mazury, 10-719 Olsztyn, Oczapowskiego 14, Poland
  2. Department of Biochemistry, Faculty of Veterinary Medicine, University of Life Sciences, 20-033 Lublin, Akademicka 12, Lublin, Poland
Download PDF Download RIS Download Bibtex

Abstract

The aim of this study was to evaluate the effect of benign prostatic hyperplasia (BPH) on nitric oxide (NO) production by spermatozoa and sperm parameters in dogs. The study was conducted on 40 intact dogs of various breeds. The dogs were assigned to two groups: BPH group (n=20) and non-affected group (n=20). The sperm concentration and motility parameters of spermatozoa were assessed using computer-assisted sperm analysis. For the assessment of sperm morphology monochromatic Diff-Quick stain was used. Plasma membrane integrity, mitochondrial membrane potential and the spermatozoa producing nitric oxide and with apoptotic-like changes were determined using fluorescent stain methods. The percentages of motile sperm, sperm with progressive motility and normal sperm were statistically significantly (p<0.05) lower in dogs with BPH than in non-affected dogs. The proportion of sperm in motility subcategory RAPID was statistically significantly (p<0.05) lower in dogs with BPH than in control dogs, whereas in the STATIC motility subcategory the proportion was significantly (p<0.05) higher in dogs with BPH. The percentage of spermatozoa producing NO was significantly (p<0.05) higher in dogs with BPH than in control dogs. In conclusion, the results of this study showed that BPH adversely affects semen quality, especially motility, in dogs. The decreased semen quality was associated with an increased proportion of spermatozoa generating NO. Further research is needed to clarify the mechanisms by which BPH affects semen quality.
Go to article

Bibliography

1. Agarwal A, Virk G, Ong C, du Plessis SS (2014) Effect of oxidative stress on male reproduction. World J Mens Health 32: 1-17.
2. Angrimani DS, Brito MM, Rui BR, Nichi M, Vannucchi CI (2020) Reproductive and endocrinological effects of Benign Prostatic Hy-perplasia and finasteride therapy in dogs. Sci Rep 10: 14834.
3. Aquino-Cortez A, Pinheiro BQ, Lima DB, Silva HV, Mota-Filho AC, Martins JAM Rodriguez-Villamil P, Moura AA, Silva LD (2017) Proteomic characterization of canine seminal plasma. Theriogenology 95: 178-186.
4. Balercia G, Moretti S, Vignini A, Magagnini M, Mantero F, Boscaro M, Ricciardo-Lamonica G, Mazzanti L (2004) Role of nitric oxide concentrations on human sperm motility. J Androl 25: 245-249.
5. Berry SJ, Strandberg JD, Saunders WJ, Coffey DS (1986) Development of canine benign prostatic hyperplasia with age. Prostate 9: 363-73.
6. Carson C 3rd, Rittmaster R (2003) The role of dihydrotestosterone in benign prostatic hyperplasia. Urology 61 (4 Suppl 1): 2-7.
7. Cochran RC, Ewing LL, Niswender GD (1981) Serum levels of follicle stimulating hormone, luteinizing hormone, prolactin, testos-terone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, and 17 be-ta-estradiol from male beagles with spontaneous or induced benign prostatic hyperplasia. Invest Urol 19: 142-147.
8. Cunto M, Ballotta G, Zambelli D (2022) Benign prostatic hyperplasia in the dog. Anim Reprod Sci 247: 107096.
9. Dearakhshandeh N, Mogheiseh A, Nazifi S, Ahrari Khafi MS, Abbaszadeh Hasiri M, Golchin-Rad K (2019) Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH induced dogs with an anti-proliferative agent called tadalafil. J Vet Pharmacol Ther 42: 665–672.
10. Domosławska A, Zduńczyk S, Kankofer M, Bielecka A (2022) Oxidative stress biomarkers in dogs with benign prostatic hyperplasia. Ir Vet J 75: 21.
11. Domosławska A, Zduńczyk S, Niżański W, Janowski T (2013) Assessment of semen quality in infertile dogs using computer-assisted sperm analysis by the Hamilton-Thorne Semen Analyser. Bull Vet Inst Pulawy 57: 429-432.
12. Doshi SB, Khullar K, Sharma RK, Agarwal A (2012) Role of reactive nitrogen species in male infertility. Reprod Biol Endocrinol 10: 109.
13. Fafula RV, Iefremova UP, Onufrovych OK, Maksymyuk HV, Besedina AS, Nakonechnyi IA, Vorobets DZ, Vorobets ZD (2018) Al-terations in Arginase-NO-synthase System of Spermatozoa in Human Subjects with Different Fertility Potential. J Med Biochem 37: 134-140.
14. Ferré-Dolcet L, Frigotto L, Contiero B, Bedin S, Romagnoli S (2022) Prostatic fluid composition and semen quality in dogs with benign prostatic hyperplasia undergoing treatment with osaterone acetate. Reprod Domest Anim 57: 72-79.
15. Flores RB, Angrimani D, Rui BR, Brito MM, Abreu RA, Vannucchi CI (2017) The influence of benign prostatic hyperplasia on sperm morphological features and sperm DNA integrity in dogs. Repro Domest Anim 52 (Suppl 2): 310-315.
16. Fontbonne A (2011) Infertility in male dogs: recent advances. Rev Bras Reprod Anim 35: 266-273.
17. Fraser L, Lecewicz M, Strzeżek J (2002) Fluorometric assessments of viability and mitochondrial status of boar spermatozoa following liquid storage. Pol J Vet Sci 5: 85-92.
18. Garner DL, Johnson LA (1995) Viability assessment of mammalian sperm using SYBR-14 and propidium iodide. Biol Reprod 53: 276–284.
19. Herrero MB, Pérez Martínez S, Viggiano JM, Polak JM, de Gimeno MF (1996) Localization by indirect immunofluorescence of nitric oxide synthase in mouse and human spermatozoa. Reprod Fertil Dev 8:931-934.
20. Krakowski L, Wąchocka A, Brodzki P, Wrona Z, Piech T, Wawron W, Chałabis-Mazurek A (2015) Sperm quality and selected bio-chemical parameters of seminal fluid in dogs with benign prostatic hyperplasia. Anim Reprod Sci 160: 20-125.
21. Lampiao F, Huussen J, du Plessis SS (2014) Effects of nitric oxide exposure on human sperm function and apoptosis markers. Open Reprod Sci J 6: 17-20.
22. Lampiao F, Strijdom H, du Plessis SS (2006) Direct nitric oxide measurement in human spermatozoa: flow cytometric analysis using the fluorescent probe, diaminofluorescein. Int J Androl 29:564-567. DOI: 10.1111/j.1365-2605.2006. 00695.x.
23. Lévy X, Niżański W, von Heimendahl A, Mimouni P (2014) Diagnosis of common prostatic conditions in dogs: an update. Reprod Domest Anim 49 (Suppl 2): 50-57.
24. Linde-Forsberg C (1991) Achieving canine pregnancy by using frozen or chilled extended semen. Vet Clin North Am Small Anim Pract 21: 467-485.
25. Luo Y, Zhu Y, Basang W, Wang X, Li C, Zhou X (2021) Roles of Nitric Oxide in the Regulation of Reproduction: A Review. Front Endocrinol (Lausanne) 12: 52410.
26. Minciullo PL, Inferrera A, Navarra M, Calapai G, Magno C, Gangemi S (2015) Oxidative stress in benign prostatic hyperplasia: a sys-tematic review. Urol Int 94: 249-254.
27. Niżański W, Eberhardt M, Ochota M, Fontaine C, Levy X, Pasikowska J (2022) A Comparative Study of the Effects of Osaterone Ace-tate and Deslorelin Acetate on Sperm Kinematics and Morpho-Functional Parameters in Dogs. Animals (Basel) 12: 1548.
28. Orzołek A, Zasiadczyk Ł, Wysocki P, Kordan W, Krysztofiak P (2018) Relation between nitric oxide (NO) level in semen and certain properties of boar spermatozoa stored at 17°C. Pol J Vet Sci 21: 423-426.
29. Paoli D, Gallo M, Rizzo F, Baldi E, Francavilla S, Lenzi A, Lombardo F, Gandini L (2011) Mitochondrial membrane potential profile and its correlation with increasing sperm motility. Fertil Steril 95: 2315-2319.
30. Polisca A, Troisi A, Fontaine E, Menchetti L, Fontbonne A (2016) A retrospective study of canine prostatic diseases from 2002 to 2009 at the Alfort Veterinary College in France. Theriogenology 85: 835-840.
31. Ramaswamy S, Weinbauer GF (2015) Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone. Spermatogenesis 4: e996025.
32. Rijsselaere T, Van Soom A, Maes D, Verberckmoes S, de Kruif A (2004) Effect of blood admixture on in vitro survival of chilled and frozen-thawed canine spermatozoa. Theriogenology 61: 1589-1602.
33. Rosselli M, Dubey RK, Imthurn B, Macas E, Keller PJ (1995) Effects of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Hum Reprod 10: 1786-1790.
34. Ruel Y, Barthez PY, Mailles A, Begon D (1998) Ultrasonographic evaluation of the prostate in healthy intact dogs. Vet Radiol Ultra-sound 39: 212-6.
35. Smith J (2008) Canine prostatic disease: a review of anatomy, pathology, diagnosis, and treatment. Theriogenology 70: 375-383.
36. Strzeżek R, Szemplińska K, Filipowicz K, Kordan W (2015) Semen characteristics and selected biochemical markers of canine seminal plasma in various seasons of the year. Pol J Vet Sci 18: 13-18.
37. Thomas CA, Garner DL, DeJarnette JM, Marshall CE (1998) Effect of cryopreservation of bovine sperm organelle function and viability as determined by flow cytometry. Biol Reprod 58: 786-793.
38. Tong Y, Zhou RY (2020) Review of the roles and interaction of androgen and inflammation in benign prostatic hyperplasia. Mediators Inflamm 2020: 7958316.
39. Trzcińska M, Bryła M (2015) Apoptotic-like changes of boar spermatozoa in freezing media supplemented with different antioxidants. Pol J Vet Sci 18: 473-480.
40. Uribe P, Boguen R, Treulen F, Sánchez R, Villegas JV (2015) Peroxynitrite-mediated nitrosative stress decreases motility and mitochon-drial membrane potential in human spermatozoa. Mol Hum Reprod 21: 237-243.
41. Vital P, Castro P, Ittmann M (2016) Oxidative stress promotes benign prostatic hyperplasia. Prostate 76: 58-67.
42. Volpe S, Leoci R, Aiudi G, Lacalandra GM (2009) Relationship between motility and mitochondrial functional status in canine sperma-tozoa. Reprod Domest Anim 44 (Suppl 2): 275-278.
Go to article

Authors and Affiliations

A. Domoslawska-Wyderska
1
A. Orzołek
2
S. Zduńczyk
1
A. Rafalska
1

  1. Department of Animal Reproduction with Clinic, University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland
  2. Department of Animal Biochemistry and Biotechnology, University of Warmia and Mazury, Oczapowskiego 5, 10-719 Olsztyn, Poland
Download PDF Download RIS Download Bibtex

Abstract

The objective of this study was to evaluate the effect of a second prostaglandin F2α (PGF2α) treatment during Ovsynch on luteal regression and fertility in dairy cows, compared with standard Ovsynch. The study was conducted on 111 Holstein Friesian multiparous cows on commercial dairy farm. The cows in the experimental group (n=48) received two treatments of PGF2α 24 hours apart during Ovsynch. The cows in the control group (n=63) were synchronized with standard Ovsynch. To assess the progesterone (P4) concentration blood samples were collected at the day of PGF2α treatment and at the 2nd GnRH treatment. Pregnancy was evaluated by ultrasound examination 37-40 days after timed artificial insemination (TAI) by ultrasound. Cows diagnosed pregnant were re-examined between days 70-80 after TAI. The percentage of cows with complete corpus luteum (CL) regression (P4<0.5 ng/ml at the time of the 2nd GnRH treatment) was 89.6 % after two PGF2α treatments and 88.9 % after one PGF2α treatment. There were no statistically significant differences (p>0.05) in the pregnancies per artificial insemination (P/AI) between the experimental and control group (P/AI). However, the pregnancy loss rate was lower in cows receiving two PGF2α treatments than in the control animals (0.0 % vs. 6.4 %; p<0.05). In conclusion, the second PGF2α treatment during Ovsynch protocol had no significant effect on CL regression and P/AI in dairy cows. The pregnancy losses until days 75-80 after TAI were significantly lower after two PGF2α treatments than after one PGF2α treatment.

Go to article

Authors and Affiliations

A. Nowicki
W. Barański
D. Tobolski
S. Zduńczyk
T. Janowski
Download PDF Download RIS Download Bibtex

Abstract

A clinical trial was performed to evaluate the therapeutic efficacy of osaterone acetate (OSA) in the treatment of benign prostatic hyperplasia (BPH) in dogs. Osaterone acetate (Ypozane, Virbac) was administered orally at a dose of 0.25 mg/kg body weight once a day for seven days to 23 dogs with BPH. During the 28-day trial, the dogs were monitored five times for their clinical signs and prostate volume. The OSA treatment promoted rapid reduction of clinical scores to 73.2% on day 7 and to 5.9% on day 28 (p<0.05). Osaterone acetate induced the complete clinical remission in approximately 83.0% of the dogs on day 28. The prostate volume regressed to 64.3% of the pretreatment volume after two weeks of the treatment (p<0.05) and to 54.7% at the end of the trial (p<0.05). In conclusion, OSA quickly reduced clinical signs and volume of the prostate glands in dogs with BPH.

Go to article

Authors and Affiliations

P. Socha
S. Zduńczyk
D. Tobolski
T. Janowski
Download PDF Download RIS Download Bibtex

Abstract

The aim of the study was to investigate the influence of cystic ovarian follicles (COFs) occurring after puerperium on fertility and the effect of their treatment with progesterone releasing device on reproductive performance in dairy cows. The study was carried out in 3 herds of Polish Holstein-Friesian cows under herd health program. COFs were diagnosed by ultrasound above 60 days p.p. They were defined as follicular structures with a diameter > 2.5 cm in the absence of a corpus luteum at two repeated examinations at the 14-days interval. On the day of COF diagnosis blood samples were collected to measure progesterone (P4) concentration. On the basis of the wall thickness measurement and progesterone concentration at the first examination, the COFs were differentiated into follicular and luteal cysts. The experimental group consisted of 23 animals with COF. The cows were treated with PRID Delta (Ceva Animal Health, Poland), containing 1.55 g of progesterone, for 7 days. The cows without oestrus signs within 14 days after treatment were re-examinated. If COF persisted, the cows were treated again with PRID Delta. The treatment was repeated maximum three times. Fifteen cows with ovarian cysts were left untreated and served as a control group. The cows with COF were matched to healthy cows without COF. The cows with COF had worse fertility performances compared to cows without COF. There were significant (p<0.05) differences in conception rates, number of services per conception and days open between these groups. Compared with non-treated cows with COF, in cows with COF treated with PRID Delta conceptions rates and number of services per conception were similar, but the days open were significantly (p<0.05) lower in cows treated than in non-treated (183.3 days vs. 277.6 days). There were no differences in reproductive performances between the follicular and luteal cysts in treated and non-treated cows. In conclusion, the results of our study confirm the negative impact of COF after puerperium on fertility in dairy cows. Furthermore the results indicate the usefulness of PRID Delta for the treatment of COF occurring after the puerperium regardless of cysts type.

Go to article

Authors and Affiliations

M. Rudowska
W. Barański
S. Zduńczyk
D. Tobolski
T. Janowski

This page uses 'cookies'. Learn more