The article proves a particular bias in the agricultural land use for assessing the ecological and economic efficiency of only cost indicators. The methodology for evaluating the ecological and economic efficiency of agricultural land use by the energy content of foods is considered. The purpose of the article is to consider the methodology and justification of the practical significance of assessing the environmental and economic efficiency of the agricultural land use by the energy content of products. The article presents the initial data for correlation-regression analysis on the average performance of agricultural producers of Ukraine to determine the weight of each indicator.We used land statistical collections, National reports on the state of the environment in Ukraine for the period 2012–2018. The analysis was carried out based on the average performance indicators of agricultural producers of Ukraine to determine the weight of factors and leverage on the ecological and economic efficiency of agricultural land use. The output of a unit of land in relative terms through exchange energy is not only a kind of indicator, a criterion for the efficient use of agricultural land but also a criterion for the effectiveness of all production activities of agricultural producers, a particular district, and even regions. The main advantage of the proposed approach is the focus on achieving the ultimate goal of agricultural production, which allows us to recommend it for extended use in assessing the ecological and economic efficiency of agricultural land use.