There exist some possibilities for simultaneous delivery of laser radiation and ultrasounds of low frequency and high intensity: introducing ultrasound oscillations in the optical fiber by the rigid connection of the fiber to the vibrating element and non-contact influence of the ultrasonic wave on the laser beam. The article presents the results of Matlab simulations and experimental studies of influence of the ultrasonic wave on the laser beam. A role of the air gap, and its influence on laser-ultrasonic transmission in optical fiber was examined. Advantages and disadvantages of both solutions of interaction of ultrasonic and optical waves in, e.g., surgical applications are discussed.