This paper describes the simulation, exergy analysis and comparison of two commonly applied liquefaction of technologies natural gas, namely: propane precooled mixed refrigerant process (C3MR) and dual mixed refrigerant process (DMR) alongside two modifications of each employing end flash systems. The C3MR and DMR process schemes were simulated using the commercial software to mathematically model chemical processes. These schemes were then analysed using energy and exergy calculations to determine their performances. The exergy efficiency for the C3MR processes without end flash system, with simple end flash system and extended end flash system were evaluated as 29%, 31%, and 33%, respectively, while the exergy efficiency for the DMR processes without end flash system, with simple end flash system, and extended end flash system were evaluated as 26%, 25.5%, and 30%, respectively. The results achieved show that the extended end flash system versions of the schemes are most efficient. Furthermore, the exergy analysis depicted that the major equipment that must be enhanced in order to improve the cycle exergy efficiencies are the compressors, heat exchangers, and coolers.