The article will consider the possibility of using sources in modernising the biological study of existence in history on the basis of selected trends of “modern historiography”. The problem of sources is considered in the context of the use of anthropology of knowledge, historical anthropology, microhistory, and chaos theory in historical-medical research. In this process, I see an opportunity to look for new research spaces and, therefore, ask new questions to source messages or to search for new ones. Therefore, it is important not to forget about the need to base the narrative on the source while introducing methodological innovations.