Searching for new refrigerants is one of the most significant scientific problems in refrigeration. There are ecological refrigerants commonly known: H2O and CO2. H2O and CO2 known as natural refrigerants, but they have problems:a high freezing point of H2O and a low triple point of CO2. These problems can be solved by the application of a hybrid sorption-compression refrigeration cycle. The cycle combines the application possibility of H2O in the high temperature sorption stage and the low temperature application of CO2 in the compression stage. This solution gives significant energy savings in comparison with the two-stage compressor cycle and with the one-stage transcritical CO2 cycle. Besides, the sorption cycle may be powered by low temperature waste heat or renewable heat. This is an original idea of the authors. In the paper an analysis of the possible extension of this solution for high capacity industrial refrigeration is presented. The estimated energy savings as well as TEWI (Total Equivalent Warming Impact) index for ecological gains are calculated.