Recent works of the authors, concerning the future of urban regions, are synthesised in the paper. Three methodological paths – focused on exploring and creating the future of urban regions – are the backbone of the presented work. Within the fi rst path, creation of regional future by applying the concept of intellectual and strategic challenges is recommended. Second path introduces a new perspective for the future, based upon vehicles. A new philosophy of urban and regional growth emerges here. Third path is a new approach towards creation of regional specialisations in a contemporary notion of technological and creative economy.