The prefabricated concrete frame structure system has advantages such as short construction period and good seismic performance, but its deformation and energy dissipation capacity are poor under earthquake action, making it prone to damage. By improving the analysis and simulation functions of existing finite element analysis for prefabricated structures, the engineering applicability of the analysis algorithm has been improved. Then, a finite element model has been established for collaborative optimization, and a parameterized optimization scheme that meets the seismic reduction requirements has been obtained. The results show that the optimization method proposed in the study has a better effect in seeking the minimum cost, and meets the design requirements of the specification. The optimization scheme of prefabricated concrete frames designed by the research institute based on finite element analysis can efficiently optimize various parameters, greatly improving the structure energy dissipation and seismic performance.